Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (60)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Orvieto, R.
Right arrow Articles by Ben-Rafael, Z.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Orvieto, R.
Right arrow Articles by Ben-Rafael, Z.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 10, No. 1, pp. 24-27, 1995
© 1995 European Society of Human Reproduction and Embryology

Interleukin-2 and ovarian hyperstimulation syndrome: a pilot study

R. Orvieto1, I. Voliovitch1, P. Fishman2 and Z. Ben-Rafael1,3

1 Department of Obstetrics and Gynaecology, Golda Medical Centre (Hasharon Hospital), Petah Tiqva, and Sackler School of Medicine, Tel Aviv University Tel Aviv 2 Haematology Research Unit, Golda Medical Centre (Hasharon Hospital), Petah Tiqva, and Bar Ilan University Ramat Gan, Israel

Correspondence: 3To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Golda Medical Centre, Hasharon Hospital, Petah Tikva 49372, Israel

A prospective case-controlled study was conducted to evaluate the association between the concentrations of interleukin-2 (IL-2) in human follicular fluid obtained at the time of oocyte collection for in-vitro fertilization (IVF) and the development of ovarian hyperstimulation syndrome (OHSS). Follicular fluid was obtained at the time of oocyte collection for IVF consecutively from 40 patients at risk of developing OHSS. Among the 40 patients participating in the study, seven subsequently developed OHSS. Their follicular fluid samples, together with those of an additional seven patients matched by age who did not develop OHSS, were tested for osmolality, total protein content and IL-2 concentrations, and mean serum oestradiol concentrations at the time of human chorionic gonadotrophin (HCG) administration and the mean number of aspirated oocytes were also measured. Follicular fluid IL-2 concentrations were significantly higher (P < 0.002) in the OHSS group as compared to the control group. No significant differences were found between the two groups regarding the mean serum oestradiol concentration on the day of HCG administration, or the mean number of aspirated oocytes, follicular fluid osmolality, or total protein concentrations. This study suggests an association between follicular fluid IL-2 concentration and OHSS. IL-2 is known to cause ‘vascular leak syndrome’, which resembles OHSS. These observations, together with the established interaction between the immune and the reproductive systems, may suggest a pivotal role of IL-2 in the pathogenesis of OHSS.

Key words: cytokines/interleukin-2/ovarian hyperstimulation syndrome/pathogenesis/prediction

Submitted on March 25, 1994; accepted on August 2, 1994.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
S. R. Soares, R. Gomez, C. Simon, J. A. Garcia-Velasco, and A. Pellicer
Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome
Hum. Reprod. Update, April 2, 2008; (2008) dmn008v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Orvieto
Vascular endothelial growth factor production by circulating immune cells is elevated in ovarian hyperstimulation syndrome
Hum. Reprod., November 1, 2007; 22(11): 3042 - 3042.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Onalan, B. Selam, Y. Baran, M. Cincik, R. Onalan, U. Gunduz, A. U. Ural, and R. Pabuccu
Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF
Hum. Reprod., September 1, 2005; 20(9): 2391 - 2395.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
R. Orvieto
Controlled Ovarian Hyperstimulation--An Inflammatory State
Reproductive Sciences, October 1, 2004; 11(7): 424 - 426.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
R. Orvieto, R. Chen, J. Ashkenazi, A. Ben-Harush, J. Bar, and B. Fisch
C-reactive protein levels in patients undergoing controlled ovarian hyperstimulation for IVF cycle
Hum. Reprod., February 1, 2004; 19(2): 357 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Orvieto
Prediction of ovarian hyperstimulation syndrome: Challenging the estradiol mythos
Hum. Reprod., April 1, 2003; 18(4): 665 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. Manau, J. Balasch, W. Jimenez, F. Fabregues, S. Civico, R. Casamitjana, M. Creus, and J. A. Vanrell
Follicular fluid concentrations of adrenomedullin, vascular endothelial growth factor and nitric oxide in IVF cycles: relationship to ovarian response
Hum. Reprod., June 1, 2000; 15(6): 1295 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
R. Orvieto and Z. Ben-Rafael
Ovarian Hyperstimulation Syndrome: A New Insight Into an Old Enigma
Reproductive Sciences, May 1, 1998; 5(3): 110 - 113.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.