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Human Reproduction, Vol. 10, No. 1, pp. 91-93, 1995
© 1995 European Society of Human Reproduction and Embryology

Intrafollicular insemination for the treatment of infertility

Sinikka Nuojua-Huttunen1, Leena Tuomivaara2, Kaisa Juntunen2, Candido Tomás, Antti Kauppila and Hannu Martikainen

Department of Obstetrics and Gynecology, University of Oulu Kajaanintie, 90220 Oulu, Finland 2 The Family Federation of Finland Kajaanintie, 90220 Oulu, Finland

Correspondence: 1To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, University of Oulu, Kajaanintie, SF-90220 Oulu, Finland

The effectiveness of intrafollicular insemination (IFI) for the treatment of non-tubal infertility was investigated in a pilot study. A total of 50 infertility patients with normal tubal function verified by laparoscopy or hysterosalpingography were stimulated with clomiphene citrate/human menopausal gonadotrophin. Washed spermatozoa were injected into one to three pre-ovulatory follicles via vaginal puncture 12 or 30 h after human chorionic gonadotrophin administration. Natural progesterone was given for luteal support. The IFI procedure was technically very simple and convenient for the patient and no complications were recorded. One normal intra-uterine pregnancy resulted. The results indicate that by comparison with other assisted reproductive technologies IFI is very inefficacious for treating non-tubal infertility. Our data suggest that the intrafollicular environment in the pre-ovulatory period is not favourable for fertilization.

Key words: assisted reproductive technology/fertilization/infertility/intrafollicular insemination

Submitted on July 8, 1994; accepted on September 9, 1994.


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