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Human Reproduction, Vol. 10, No. 1, pp. 94-97, 1995
© 1995 European Society of Human Reproduction and Embryology

Risk of thromboembolism in relation to an in-vitro fertilization programme: three case reports

M.H. Aurousseau1, M.M. Samama2, A. Belhassen3, F. Herve4 and J.N. Hugues5

1 Laboratoire d'Hématologie Hôpital Jean Verdier, Bondy 93140 3 Service de Chirurgie Jean Verdier, Bondy 93140 4 Service de Gynécologie-Obstétrique Jean Verdier, Bondy 93140 5 Unité de Médecine de la Reproduction Jean Verdier, Bondy 93140 2 Laboratoire d'Hématologie Hôtel-Dieu de Paris, Paris 75004, France

Severe thrombotic events following ovarian stimulation for in-vitro fertilization (IVF) procedures in three women are reported. None of these patients presented any concomitant clinical sign of ovarian hyperstimulation syndrome. Coagulation inhibitors were in the normal range but cardiovascular risk factors were present. It is postulated that early thrombosis could be favoured by high endogenous plasma oestrogen concentrations subsequent to ovarian stimulation when associated with another risk factor. Our data are discussed in relation to previous publications. It is suggested that risk factors must be considered individually before each IVF attempt. In patients at high risk, clinical management of the post-transfer period is recommended.

Key words: in-vitro fertilization/oestrogens/risk factors/thrombosis

Submitted on June 10, 1994; accepted on September 28, 1994.


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