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Human Reproduction, Vol. 10, No. 1, pp. 98-102, 1995
© 1995 European Society of Human Reproduction and Embryology

Mucin gene expression in the human endocervix

Jean-Pierre Audie1, Daniel Tetaert1, Pascal Pigny1,2, Marie-Pierre Buisine1, Anne Janin3, Jean-Pierre Aubert1,4, Nicole Porchet1,4 and Arnold Boersma1,2,5

1 Unité INSERM 377 Place de Verdun 2 Laboratoire de Biochimie Endocrinologique USN A 3 Laboratoire d'Anatomie Cytologie Pathologique C, Hopital A.Calmette C H et U, Lille, France 4 Laboratoire de Biochimie, Hopital C.Huriez C H et U, Lille, France

Correspondence: 5To whom correspondence should be addressed at: Unité INSERM 377, Place de Verdun, 59045 Lille cedex, France

In the human uterine endocervix, five out of the six human mucin genes investigated (MUC 2, MUC 3, MUC 4, MUC 5AC, MUC 5B and MUC 6) are expressed, whereas in some other mucosae the hybridization pattern demonstrates the expression of only two or three of these genes. The most intense labelling by in-situ hybridization is obtained significantly with MUC 4, predominantly during the luteal phase. The expression of the MUC 4 gene appears to be influenced by the oestro-progesterone ratio. During the ovulatory cycle, there are only a few differences concerning the variations of expression of all other MUC genes.

Key words: endocervix/in-situ hybridization/mucin gene

Submitted on June 8, 2005; accepted on September 13, 1994.


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