Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (35)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Nip, M.M.C.
Right arrow Articles by Hancock, K.W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nip, M.M.C.
Right arrow Articles by Hancock, K.W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 10, No. 10, pp. 2564-2569, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Autoantibodies and antisperm antibodies in sera and follicular fluids of infertile patients; relation to reproductive outcome after in-vitro fertilization

M.M.C. Nip1, P.V. Taylor1,3, A.J. Rutherford2 and K.W. Hancock

1Division of Obstetrics and Gynaecology, School of Medicine, University of Leeds, D Floor Leeds 2 LS2 9NS, UK 2Assisted Conception Unit, C Floor, Clarendon Wing (Leeds General Infirmary) Leeds 2 LS2 9NS, UK

Correspondence: *To whom correspondence should be addressed

Immune reactions have effects at various concentrations in the reproductive process and autoantibodies may have an impact on fertility and the outcome of assisted conception. We measured the prevalence of and relation between antibodies to smooth muscle, nuclear, phospholipid and sperm antigens, and concentrations of immunoglobulins G, M and A and complement components C3 and C4, in the sera and follicular fluids of women with unexplained infertility (n = 30), endometriosis (n = 20), tubal infertility (n = 50) and the sera of 20 normal non-pregnant women. We assessed fertilization and successful pregnancy rates in relation to antibody status of infertile women after in vitro fertilization. All antibodies had a higher prevalence in infertile women compared with controls and this was significant for smooth muscle antibody in endometriosis (P < 0.05); anticardiolipin antibody in tubal infertility P < 0.05); and antisperm antibody in all types of infertility (P < 0.001). There was no relation between presence of specific antibodies in serum or between serum and follicular fluids. Total biochemical pregnancy rate was higher with endometriosis (P = 0.05) but clinical pregnancy and live birth rates did not differ between groups or in relation to antibody status. Significant differences in immunoglobulin and complement components occurred in women with and without successful biochemical pregnancy.

Key words: autoantibodies/endometriosis/infertility/IVF/sperm antibody


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
S. M. Nelson and I. A. Greer
The potential role of heparin in assisted conception
Hum. Reprod. Update, November 1, 2008; 14(6): 623 - 645.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Matsubayashi, T. Sugi, T. Arai, M. Shida, A. Kondo, T. Suzuki, S.-i. Izumi, and J. A. McIntyre
Antiphospholipid antibodies in serum and follicular fluid: is there a correlation with IVF implantation failure?
Hum. Reprod., November 1, 2007; 22(11): 3043 - 3044.
[Full Text] [PDF]

Home page
 LupusHome page
J D. Alves, E L Radway-Bright, S Lee, B Grima, J Hothersall, C T Ravirajan, and D A Isenberg
Antiphospholipid antibodies are induced by in vitro fertilization and correlate with paraoxonase activity and total antioxidant capacity of plasma in infertile women
Lupus, May 1, 2005; 14(5): 373 - 380.
[Abstract] [PDF]

Home page
 Exp. Biol. Med.Home page
S. S. Koide, L. Wang, and M. Kamada
Antisperm Antibodies Associated with Infertility: Properties and Encoding Genes of Target Antigens
Experimental Biology and Medicine, July 1, 2000; 224(3): 123 - 132.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
J. Luborsky, B. Llanes, R. Roussev, and C. Coulam
Ovarian antibodies, FSH and inhibin B: independent markers associated with unexplained infertility
Hum. Reprod., May 1, 2000; 15(5): 1046 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. B. DIEKMAN, E. J. NORTON, K. L. KLOTZ, V. A. WESTBROOK, H. SHIBAHARA, S. NAABY-HANSEN, C. J. FLICKINGER, and J. C. HERR
N-linked glycan of a sperm CD52 glycoform associated with human infertility
FASEB J, August 1, 1999; 13(11): 1303 - 1313.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
T. Eldar-Geva, C. Wood, N. Lolatgis, L. Rombauts, G. Kovacs, J. Fuscaldo, and A.O. Trounson
Cumulative pregnancy and live birth rates in women with antiphospholipid antibodies undergoing assisted reproduction
Hum. Reprod., June 1, 1999; 14(6): 1461 - 1466.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P.E. Egbase, M. Al Sharhan, M. Diejomaoh, and J.G. Grudzinskas
Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer
Hum. Reprod., June 1, 1999; 14(6): 1483 - 1486.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
D. Ware Branch and H. Hatasaka
Review : Antiphospholipid antibodies and infertility: Fact or fallacy
Lupus, January 1, 1998; 7(2_suppl): S90 - S94.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.