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Human Reproduction, Vol. 10, No. 11, pp. 2824-2828, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Treatment of severe male immunological infertility by intracytoplasmic sperm injection

A. Lähteenmäki1, I. Reima and O. Hovatta

Infertility Clinic, The Family Federation of Finland PO Box 849, 00101 Helsinki, Finland

Correspondence: 1To whom correspondence should be addressed

A total of 29 infertile couples (group A) with male antisperm antibodies detected by the mixed antiglobulin reaction (MAR) and partly by flow cytometry (n = 21) were treated using an intracytoplasmic sperm injection (ICSI) technique to assist fertilization. In all, 22 of them had shown a poor fertilization rate (6%) in previous in-vitro fertilization (IVF) treatments. The fertilization and cleavage rates in ICSI, 79 and 89% respectively, were similar to those in a MAR-negative group (group B; n = 20) injected because of male infertility (68 and 93% respectively). A third group (group C; n = 37) with male immune infertility was treated by conventional IVF. All these couples had at least one oocyte fertilized, but the overall fertilization rate (44%) in group C was significantly poorer (P < 0.001) than that in the two ICSI groups. However, the embryo quality was lower in group A compared with that in the other groups. A total of 13 pregnancies resulted in group A (46%), of which five ended in miscarriage. None of the six pregnancies (30%) in group B aborted during the first trimester. These results reveal, for the first time, that ICSI offers a good chance of fertilization for couples with male immunological infertility. However, post-fertilization events may compromise these results because of factors not yet clearly understood.

Key words: antisperm antibodies/in-vitro fertilization/intracytoplasmic/sperm injection


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