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Human Reproduction, Vol. 10, No. 11, pp. 2880-2886, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Genetic risk in micromanipulative assisted reproduction

D. Meschede1,4, C.De Geyter2, E. Nieschlag3 and J. Horst1

1Institute of Human Genetics D-48149 Münster, Germany 2Women's Hospital D-48149 Miinster, Germany 3Institute of Reproductive Medicine of the University D-48149 Münster, Germany

Correspondence: 4 To whom correspondence should be addressed at: Institute of Human Genetics, Vesaliusweg 12–14, D-48149 Miinster, Germany

The empirical data on pregnancy outcome after intracytoplasmic sperm injection (ICSI) are encouraging, but still insufficient to rule out definitely adverse genetic or teratological effects. We analyse potential adverse effects of ICSI by applying general principles of genetic and teratological risk assessment. The role of gamete micromanipulation as a possible teratogen is discussed. We consider whether ICSI patients are at increased risk for carrying and propagating genetic lesions of different kinds. The possible interference of ICSI with genomic imprinting and pre-zygotic sperm selection is reviewed and we discuss the potentially protective role of DNA repair in oocytes. Considering the available empirical data and the conclusions from our theoretical analysis it appears that neither lassitude nor over-concern about adverse effects of ICSI are justified.

Key words: assisted reproduction/genetic disease/intracytoplasmic-sperm injection/risk evaluation/teratogenesis


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