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Human Reproduction, Vol. 10, No. 12, pp. 3091-3096, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone

F. Ubaldi1, J. Smitz, A. Wisanto, H. Joris, J. Schiettecatte, M.P. Derde, E. Borkham, A. van Steirteghem and P. Devroey

Centre for Reproductive Medicine, Dutch-speaking Brussels Free University Laarbeeklaan 101, 1090 Brussels, Belgium

Correspondence: 1To whom correspondence should be addressed

The effect of elevated serum progesterone concentrations (>1 ng/1) on or before the day of human chorionic gonadotrophin (HCG) injection on the outcome of women receiving gonadotrophin-releasing hormone analogue (GnRHa)/ human menopausal gonadotrophin (HMG) for ovarian stimulation prior to intracytoplasmic sperm injection (ICSI) was evaluated. A total of 1275 ICSI cycles were analysed retrospectively. In 53 cycles (4.5%), serum progesterone concentrations were > 1 ng/ml. Patients in the high progesterone group had significantly higher oestradiol and luteinizing hormone concentrations on the day of HCG injection. The characteristics of the cumulus-corona cell complexes and the nuclear maturity of the oocytes were similar in the groups of patients with high and low serum progesterone levels. Fertilization and cleavage rates as well as embryo quality were not different in the two groups. No difference in implantation or clinical pregnancy rates was observed between the high progesterone and low progesterone groups. Moreover, the cumulative exposure to progesterone during the follicular phase, as expressed by the area under the curve (AUC), and the duration of exposure to high serum progesterone levels (>1 ng/ml) were not significantly different between pregnant and non-pregnant women in the high progesterone group. We conclude that in ICSI cycles pretreated with GnRHa, increased serum progesterone concentrations on or before the day of HCG injection do not affect ICSI outcome.

Key words: follicular phase/GnRHa/HMG/ovarian stimulation/intracytoplasmic/sperm injection/serum progesterone


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