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Human Reproduction, Vol. 10, No. 12, pp. 3322-3324, 1995
© 1995 European Society of Human Reproduction and Embryology

other

Case report: Transient diabetes insipidus in pregnancy – a consequence of enhanced placental clearance of arginine vasopressin

Steven G. Soule1, John P. Monson2 and Howard S. Jacobs1,3

1Endocrine Unit, Department of Medicine, University College London Medical School, The Middlesex Hospital London WIN 8AA 2Department of Endocrinology, The Royal London Hospital London El, UK

Correspondence: 3To whom correspondence should be addressed

We report a patient who presented with transient diabetes insipidus in pregnancy on a background of previous postoperative diabetes insipidus following surgical excision of a prolactinoma. The patient illustrates how the complex changes in water homeostasis occurring during normal pregnancy may unmask latent diabetes insipidus. The major factors operating appear to be a physiological reduction in the thresholds for thirst and arginine vasopressin secretion coupled with a substantial increase in placental clearance of arginine vasopressin. Reversal of these changes after delivery results in normalization of the disordered water homeostasis, with consequent resolution of the diabetes insipidus.

Key words: arginine vasopressin/diabetes insipidus/pregnancy


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