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Human Reproduction, Vol. 10, No. 2, pp. 425-430, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Fertilization and early embryology: CD44 is expressed throughout pre-implantation human embryo development

S. Campbell1, H.R. Swann1, J.D. Aplin1,2,3, M.W. Seif1, S.J. Kimber2 and M. Elstein1

1Department of Obstetrics and Gynaecology, University Hospital of South Manchester Nell Lane, Manchester M20 2LR 2School of Biological Sciences, University of Manchester Oxford Road, Manchester M13 9PT, UK

Correspondence: 3To whom correspondence should be addressed

The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8–11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.

Key words: adhesion molecule/CD44/cumulus/embryo/oocyte


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