Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (67)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Liu, J.
Right arrow Articles by Van Steirteghem, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, J.
Right arrow Articles by Van Steirteghem, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 10, No. 3, pp. 626-629, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Andrology: Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia

Jiaen Liu1, Zsolt Nagy, Hubert Joris, Herman Tournaye, Paul Devroey and André Van Steirteghem

Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel) Laarbeeklaan 101, B-1090 Brussels, Belgium

Correspondence: 1To whom correspondence should be addressed

Globozoospermia or round-headed spermatozoa is a rare type of teratozoospermia where the acrosome is absent resulting in male infertility with no known therapy. A few studies have shown that round-headed spermatozoa cannot bind to or penetrate the zona pellucida, and no normal fertilization has been observed in in-vitro fertilization (IVF) after insemination of human oocytes with round-headed spermatozoa. In this study, the fertilization capacity of round-headed spermatozoa after intracytoplasmic sperm injection (ICSI) into human oocytes has been examined. In pre-clinical experiments, 45 oocytes were injected; 41 oocytes were intact after injection, 15 oocytes were fertilized normally, and 13 of these 15 oocytes developed further in vitro. ICSI was carried out in 11 treatment cycles of seven infertile couples with globozoospermia. Normal fertilization and embryo transfer occurred in four cycles (three patients). Positive serum human chorionic gonadotrophin was observed in three cycles (two patients); one patient had a pre-clinical abortion and the other patient became pregnant twice: the first pregnancy was ectopic and the second pregnancy is a twin pregnancy which is currently at 16 weeks of gestation.

Key words: fertilization/globozoospermia/intracytoplasmic sperm injection/male-factor infertility/oocyte maturation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
The ESHRE Capri Workshop Group
Intracytoplasmic sperm injection (ICSI) in 2006: Evidence and Evolution
Hum. Reprod. Update, November 1, 2007; 13(6): 515 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
A.H.D.M. Dam, I. Feenstra, J.R. Westphal, L. Ramos, R.J.T. van Golde, and J.A.M. Kremer
Globozoospermia revisited
Hum. Reprod. Update, January 1, 2007; 13(1): 63 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
O. Pirrello, N. Machev, F. Schimdt, P. Terriou, Y. Menezo, and S. Viville
Search for mutations involved in human globozoospermia
Hum. Reprod., May 1, 2005; 20(5): 1314 - 1318.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Schmiady, W. Schulze, I. Scheiber, and B. Pfuller
High rate of premature chromosome condensation in human oocytes following microinjection with round-headed sperm: Case report
Hum. Reprod., May 1, 2005; 20(5): 1319 - 1323.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Takeuchi, L. T. Colombero, Q. V. Neri, Z. Rosenwaks, and G. D. Palermo
Does ICSI require acrosomal disruption? An ultrastructural study
Hum. Reprod., January 1, 2004; 19(1): 114 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Vicari, A. Perdichizzi, A. De Palma, N. Burrello, R. D'Agata, and A. E. Calogero
Globozoospermia is associated with chromatin structure abnormalities: Case report
Hum. Reprod., August 1, 2002; 17(8): 2128 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. B. Zeyneloglu, V. Baltaci, H. E. Duran, E. Erdemli, and S. Batioglu
Achievement of pregnancy in globozoospermia with Y chromosome microdeletion after ICSI: Case report
Hum. Reprod., July 1, 2002; 17(7): 1833 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Stone, F. O'Mahony, Y. Khalaf, A. Taylor, and P. Braude
A normal livebirth after intracytoplasmic sperm injection for globozoospermia without assisted oocyte activation: Case Report
Hum. Reprod., January 1, 2000; 15(1): 139 - 141.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.