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Human Reproduction, Vol. 10, No. 4, pp. 797-800, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Endocrinology: The effect of high-dose medium- and long- term progestogen exposure on endometrial vessels

Jing Yu Song1,3, Robert Markham1, Peter Russell2, Theo Wong1, Lawrence Young1 and Ian S. Fraser1

1Department of Obstetrics and Gynaecology, University of Sydney NSW 2006 2Department of Anatomical Pathology, Royal Prince Alfred and King George V Hospitals Sydney, Australia

Correspondence: 3To whom correspondence should be addressed

A total of 19 paraffin-embedded endometrial tissue blocks were obtained from high-dose progestogen-exposed patients. A labelled streptavidin—biotin—alkaline phosphatase method was used with antibodies against von Willebrand factor (vWF) and CD34. The density of CD34 and vWF positive (CD34+ and vWF+) vessels in progestogen-exposed endometria (103 ± 9.6/mm2 and 106 ± 8.7/mm2) was significantly lower than in endometria from women with normal cycles (169 ± 9.3/mm2 and 136 ± 8.0/mm2) (P < 0.05). In women with normal menstrual cycles the concentration of CD34+ vessels was significantly higher than the number of vWF+ vessels (P = 0.0001). By comparison, the concentration of CD34+ vessels was similar to the concentration of vWF+ vessels in progestogen-exposed endometria. The ratios of vascular density as determined by vWF+ and CD34+ staining in the control and progestogen groups were 0.81 and 1.05 respectively (P = 0.0001). Dilated venules were seen in the progestogen group. This study has demonstrated firstly that CD34 antibody detected the endothelial cells in a higher proportion of small endometrial vessels than vWF, and secondly that high-dose progestogen exposure significantly decreased the density of microvessels and increased the number of dilated venules in endometrium.

Key words: endometrium/immunostaining/progestogens/Q-Bend-10/von Willebrand factor


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