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Human Reproduction, Vol. 10, No. 4, pp. 804-806, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*

David B. Seifer1,4, Linda C. Giudice2, Beth A. Dsupin2, Ray V. Haning, Jr1, Gary N. Frishman1 and Henry G. Burger3

1Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Brown University School of Medicine, Women and Infants Hospital 101 Dudley Street, Providence, RI 02905 2Department of Obstetrics and Gynecology, Stanford University Medical Center Stanford, CA, USA 3Department of Obstetrics and Gynecology, Prince Henry's Institute of Medical Research, Monash Medical Center Victoria, Australia

Correspondence: 4To whom correspondence should be addressed

We determined follicular fluid concentrations of insulin-like growth factor (IGF)-I, IGF-II and inhibin as a function of day 3 serum follicle stimulating hormone (FSH) in 16 women undergoing follicular fluid aspiration in preparation for in-vitro fertilization and embryo transfer. Follicular fluid concentrations of IGF-I and IGF-II were significantly less in the ‘low’ FSH group as compared to the ‘high’ FSH group. The mean IGF-I concentration was 67.6 ng/ml [confidence intervals (CI) 51.6–92.5] in the ‘low’ FSH group compared to 87.1 ng/ml (CI 72.8–104.2; P < 0.025) in the ‘high’ FSH group. Mean IGF-II concentrations were 354.8 ng/ml (CI 297.8–422.9) in the ‘low’ FSH group compared to 489.8 ng/ml (CI 384.6–624.5; P < 0.05) in the ‘high’ FSH group. Follicular fluid inhibin concentrations did not differ between groups. These differences in follicular fluid IGF as a function of day 3 FSH may raise questions regarding the role growth factors play in the physiological processes of the ageing follicle.

Key words: follicular fluid/growth factors/ovarian reserve

*Presented at the 41st Annual Society for Gynecologic Investigation Meeting Chicago, Illinois, March 1994.


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L. Poretsky, N. A. Cataldo, Z. Rosenwaks, and L. C. Giudice
The Insulin-Related Ovarian Regulatory System in Health and Disease
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