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Human Reproduction, Vol. 10, No. 4, pp. 807-810, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Intravenous albumin does not prevent the development of severe ovarian hyperstimulation syndrome in an in-vitro fertilization programme

Esther Ng, Arthur Leader1, Paul Claman, Minerva Domingo and John E.H. Spence

Division of Gynecologic Reproductive Endocrinology and Infertility, University of Ottawa, Ottawa Civic Hospital 737 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9

Correspondence: 1To whom correspondence should be addressed

A cohort study was undertaken to compare the effect at the time of oocyte retrieval of the i.v. administration of either 1000 ml of lactated Ringer' solution or 1000 ml of a 5% solution of human albumin on in-vitro fertilization patients at risk for severe ovarian hyperstimulation syndrome (OHSS). A total of 207 patients with an oestradiol concentration > 10 000 pmol/l and/or > 15 follicles (>10 mm diameter) on the day of human chorionic gonadotrophin (HCG) injection were reviewed. Of these, 158 women received 500 ml of lactated Ringer’s solution both before and after egg retrieval, and 49 women received two infusions of 500 ml of 5% human albumin in normal saline at the time of egg retrieval. Severe OHSS developed in two patients who received human albumin and in 10 women who did not receive the albumin. This difference was not statistically significant. There were no differences between the two groups in terms of age, number of follicles punctured at transvaginal oocyte retrieval or oestradiol concentration at the time of HCG injection. The administration of a 5% human albumin solution does not prevent the development of severe OHSS in at risk patients. It does appear to blunt the severity of the condition.

Key words: human albumin/in-vitro fertilization/ovarian hyper-stimulation syndrome/prevention


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