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Human Reproduction, Vol. 10, No. 4, pp. 883-886, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Fertilization and early embryology: Combined effects of maternal age and delayed fertilization on the frequency of chromosome anomalies in mice

Hitoshi Ishikawa and Akira Endo1

Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine Yamagata 990-23, Japan

Correspondence: 1To whom correspondence should be addressed

Animal experiments indicate that both maternal age and delayed fertilization increase the incidence of chromosome errors in the offspring. In the present study, therefore, we examined how both factors act in combination. We set up normal (0 h delay) and delayed fertilization (6 h delay) subgroups in three different age groups (young, 3–4 months; middle-aged, 9–11 months; and old, 13–15 months), and compared the incidence of chromosome anomalies and other reproductive effects among them. Although the present study confirmed two previous findings that aneuploidies increase with advancing maternal age, and that polyploidies increase with delayed fertilization in mice, it was not clear whether maternal age and delayed fertilization affected the occurrence of aneuploidies either additively or multiplicatively.

Key words: aneuploidy/interactive effect/mid-gestation/polyploidy


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