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Human Reproduction, Vol. 10, No. 4, pp. 911-918, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Implantation: Leukaemia inhibitory factor in human endometrium during the menstrual cycle: cellular origin and action on production of glandular epithelial cell prostaglandin in vitro

D.-B. Chen, R. Hilsenrath, Z.-M. Yang, S.-P. Le, S.-R. Kim1, C.J. Chuong, A.N. Poindexter, III and M.J.K. Harper2

Center for Reproductive Medicine and Surgery, Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza Houston, TX 77030, USA 1Department of Obstetrics and Gynecology, Hanyang University Hospital Seoul, 133-792, Korea

Correspondence: 2To whom correspondence should be addressed at: 6550 Fannin, Smith Tower Room 825, Houston, TX 77030, USA

Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine which plays an obligatory role in mouse implantation. To investigate its potential role in the regulation of uterine function in the human, LIF secretion by isolated human endometrial glandular epithelial and stromal cells in primary culture was determined. Endometrial cells secreted a detectable amount of LIF protein during the first 48 h of culture. In the follicular and late-luteal phases, LIF secretion by both cell types was low. At every stage of the menstrual cycle, the epithelial cells secreted significantly more LIF than did stromal cells. Glandular epithelial cells of the mid-luteal phase, at the expected time of implantation in the human, secreted significantly more LIF than at other stages of the cycle. Stromal cells showed a similar, but nonsignificant, LIF secretion pattern. It could be concluded that endometrial LIF expression was dependent on cell type and stage of the menstrual cycle, and might thus play a role in human implantation. Oestradiol-17{beta} stimulated both prostaglandin (PG) F and E release by the epithelial cells in both follicular and luteal phases. PGE release during the luteal phase was greater than in the follicular phase. However, addition of recombinant human LIF did not change either PGF or PGE release in either follicular or luteal phases, in the presence or absence of oestradiol.

Key words: endometrium/human/in vitro/leukaemia inhibitory factor/prostaglandin


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