Human Reproduction, Vol. 10, No. 7, pp. 1678-1683, 1995
© 1995 European Society of Human Reproduction and Embryology
research-article |
Endocrinology: The role of luteinizing hormone in human follicle development and oocyte fertility: evidence from in-vitro fertilization in a woman with long-standing hypogonadotrophic hypogonadism and using recombinant human follicle stimulating hormone
1Department of Obstetrics and Gynaecology, Faculty of Medicine-University of Barcelona, Hospital Clínic i Provincial C/Casanova 143, 08036-Barcelona, Spain 2Reproductive Endocrinology Laboratory, Department of Obstetrics and Gynaecology, University of Edinburgh Centre for Reproductive Biology Edinburgh, Scotland, UK 3Hormonal Laboratory, Faculty of Medicine-University of Barcelona, Hospital Clínic i Provincial C/Casanova 143, 08036-Barcelona, Spain
Correspondence: 4To whom correspondence should be addressed
To evaluate the relative importance of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in follicular development and oocyte fertility in the human species, the use of recombinant human FSH, human menopausal gonadotrophin (HMG), and very highly purified urinary human FSH (FSH-HP) plus oestradiol valerate for ovarian stimulation and in-vitro fertilization (IVF) were compared in three cycles in a woman with isolated congenital gonadotrophin deficiency who had never been treated with ovarian stimulating agents. The total number of ampoules of gonadotrophins used was lower in the HMG treatment cycle. Ovarian response and IVF outcome in the three treatment cycles were as follows: (i) HMG cycle: normal follicular growth, normal pattern of oestradiol and inhibin through the menstrual cycle, high fertilization rate (93%); (ii) recombinant FSH cycle: normal follicular growth, low oestradiol and abnormal inhibin, finally poor rate of fertilization (28%); (iii) FSH-HP plus oestradiol valerate cycle: normal follicular growth, normal pattern of inhibin and poor fertilization rate (27%). Luteal plasma progesterone concentrations were much higher in the HMG treatment cycle. This case shows that FSH is the only factor required in order to induce follicular growth in the human, although LH or a product derived from its action may assist in order to achieve full follicular maturity and oocytes capable of fertilization. Though oestradiol might have a mediatory role in the process of follicular maturation, our results favour a direct primary role of LH in complete maturation of the follicle.
Key words: follicle development/FSH/IVF/LH/oocyte maturation
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Balasch, F. Fabregues, F. Carmona, R. Casamitjana, and M. Tena-Sempere Ovarian Luteinizing Hormone Priming Preceding Follicle-Stimulating Hormone Stimulation: Clinical and Endocrine Effects in Women with Long-Term Hypogonadotropic Hypogonadism J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2367 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Murray, A. K.E. Swales, R. E. Smith, M. D. Molinek, S. G. Hillier, and N. Spears Follicular growth and oocyte competence in the in vitro cultured mouse follicle: effects of gonadotrophins and steroids Mol. Hum. Reprod., February 1, 2008; 14(2): 75 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lahoud, M.A. Jefout, J. Tyler, J. Ryan, and G. Driscoll A relative reduction in mid-follicular LH concentrations during GnRH agonist IVF/ICSI cycles leads to lower live birth rates Hum. Reprod., October 1, 2006; 21(10): 2645 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balasch, F. Fabregues, J. Penarrubia, F. Carmona, R. Casamitjana, M. Creus, D. Manau, G. Casals, and J. A. Vanrell Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH Hum. Reprod., July 1, 2006; 21(7): 1884 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Platteau, A. N. Andersen, A. Balen, P. Devroey, P. Sorensen, L. Helmgaard, J.-C. Arce, and for the Menopur Ovulation Induction (MOI) Study Gr Similar ovulation rates, but different follicular development with highly purified menotrophin compared with recombinant FSH in WHO Group II anovulatory infertility: a randomized controlled study Hum. Reprod., July 1, 2006; 21(7): 1798 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bjercke, P. Fedorcsak, T. Abyholm, R. Storeng, G. Ertzeid, N. Oldereid, A. Omland, and T. Tanbo IVF/ICSI outcome and serum LH concentration on day 1 of ovarian stimulation with recombinant FSH under pituitary suppression Hum. Reprod., September 1, 2005; 20(9): 2441 - 2447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.N. Hugues, J. Soussis, I. Calderon, J. Balasch, R.A. Anderson, A. Romeu, and on behalf of the Recombinant LH Study Group Does the addition of recombinant LH in WHO group II anovulatory women over-responding to FSH treatment reduce the number of developing follicles? A dose-finding study Hum. Reprod., March 1, 2005; 20(3): 629 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. U. Meysing, H. Kanasaki, G. Y. Bedecarrats, J. S. Acierno Jr., P. M. Conn, K. A. Martin, S. B. Seminara, J. E. Hall, W. F. Crowley Jr., and U. B. Kaiser GNRHR Mutations in a Woman with Idiopathic Hypogonadotropic Hypogonadism Highlight the Differential Sensitivity of Luteinizing Hormone and Follicle-Stimulating Hormone to Gonadotropin-Releasing Hormone J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3189 - 3198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Humaidan, L. Bungum, M. Bungum, and C.Y. Andersen Ovarian response and pregnancy outcome related to mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation Hum. Reprod., August 1, 2002; 17(8): 2016 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Garcia-Campayo and I. Boime Independent Activities of FSH and LH Structurally Confined in a Single Polypeptide: Selective Modification of the Relative Potencies of the Hormones Endocrinology, December 1, 2001; 142(12): 5203 - 5211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Burgues The effectiveness and safety of recombinant human LH to support follicular development induced by recombinant human FSH in WHO group I anovulation: evidence from a multicentre study in Spain Hum. Reprod., December 1, 2001; 16(12): 2525 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balasch, E. Vidal, J. Penarrubia, R. Casamitjana, F. Carmona, M. Creus, F. Fabregues, and J. A. Vanrell Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH Hum. Reprod., August 1, 2001; 16(8): 1636 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Palter, A. B. Tavares, A. Hourvitz, J. D. Veldhuis, and E. Y. Adashi Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis? Endocr. Rev., June 1, 2001; 22(3): 389 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fawzy, R.F. Harrison, P.G. Knight, N. Groome, A. Anderson, W.R. Robertson, and A. Lambert The effect of gonadotrophins with differing LH/FSH ratios on the secretion of the various species of inhibin in women receiving IVF Hum. Reprod., June 1, 2001; 16(6): 1092 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balasch, F. Fabregues, M. Creus, B. Puerto, J. Penarrubia, and J. A. Vanrell Follicular development and hormone concentrations following recombinant FSH administration for anovulation associated with polycystic ovarian syndrome: prospective, randomized comparison between low-dose step-up and modified step-down regimens Hum. Reprod., April 1, 2001; 16(4): 652 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. L. Schattman, D. Levy, and J. Navarro LH and ovulation induction Hum. Reprod., April 1, 2001; 16(4): 803 - 804. [Full Text] [PDF]
|
|
|
|
|
|
D. P. Levy, J. M. Navarro, G. L. Schattman, O. K. Davis, and Z. Rosenwaks The role of LH in ovarian stimulation: Exogenous LH: let's design the future Hum. Reprod., November 1, 2000; 15(11): 2258 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fleming, P. Rehka, N. Deshpande, M.E. Jamieson, R.W.S. Yates, and H. Lyall Suppression of LH during ovarian stimulation: effects differ in cycles stimulated with purified urinary FSH and recombinant FSH Hum. Reprod., July 1, 2000; 15(7): 1440 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Westergaard, S. B. Laursen, and C. Y. Andersen Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction Hum. Reprod., May 1, 2000; 15(5): 1003 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.S. Sills, D. P. Levy, M. Moomjy, M. McGee, and Z. Rosenwaks A prospective, randomized comparison of ovulation induction using highly purified follicle-stimulating hormone alone and with recombinant human luteinizing hormone in in-vitro fertilization Hum. Reprod., September 1, 1999; 14(9): 2230 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. R. H. L. S. Group Recombinant Human Luteinizing Hormone (LH) to Support Recombinant Human Follicle-Stimulating Hormone (FSH)-Induced Follicular Development in LH- and FSH-Deficient Anovulatory Women: A Dose-Finding Study J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1507 - 1514. [Abstract] [Full Text]
|
|