Human Reproduction, Vol. 10, No. 7, pp. 1797-1800, 1995
© 1995 European Society of Human Reproduction and Embryology
research-article |
Prevention of post-surgical adhesion formation using aspirin in a rodent model: a preliminary report
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center (affiliated with the Sackler Faculty of Medicine, Tel Aviv) Tzrifin 70300, Israel
Correspondence: 1To whom correspondence should be addressed
Pelvic adhesions are one of the major factors which significantly and adversely affect surgery outcome due to intra-and postoperative morbidity and reduce future female fertility. Using a rodent model, we evaluated the efficacy of aspirin, a non-steroidal anti-inflammatory drug, in the prevention of adhesion formation. A total of 72 female Wistar rats received a standardized primary traumatic lesion to the right uterine horn. They were randomly divided into eight groups: group I (control) had no treatment and group II received a single pre-operative 0.70 mg aspirin. All the succeeding groups (III-VIII) received aspirin in doses of 0.35, 0.70, or 1.40 mg every 6 h for either 48 or 96 h in addition to the pre-operative aspirin (0.70 mg). All animals were killed 4 weeks later and adhesions were assessed using a modified adhesion scoring scale. The lowest adhesion score was found in the group treated with 0.35 mg of aspirin for 96 h, and the highest was found among the groups treated with either 0.70 or 1.40 mg for 48–96 h respectively (P < 0.05). These results are in line with the hypothesis that administration of a low dose of aspirin selectively inhibits the production of thromboxane A2, whereas basal prostacyclin biosynthesis is preserved. This phenomenon might contribute to reducing postoperative adhesion formation in a rat model. Thus, future studies into the prevention of adhesion formation may require the additional use of a non-steroidal anti-inflammatory drug, for which aspirin deserves further attention, before extrapolation into human therapy.
Key words: adhesions/aspirin/peritoneal healing/rodents
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Nappi, A. Di Spiezio Sardo, E. Greco, M. Guida, S. Bettocchi, and G. Bifulco Prevention of adhesions in gynaecological endoscopy Hum. Reprod. Update, July 1, 2007; 13(4): 379 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ozcelik, I.S. Serin, M. Basbug, S. Uludag, F. Narin, and M. Tayyar Effect of melatonin in the prevention of post-operative adhesion formation in a rat uterine horn adhesion model Hum. Reprod., August 1, 2003; 18(8): 1703 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ferland, D. Mulani, and P.K. Campbell Evaluation of a sprayable polyethylene glycol adhesion barrier in a porcine efficacy model Hum. Reprod., December 1, 2001; 16(12): 2718 - 2723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Guvenal, A. Cetin, H. Ozdemir, O. Yanar, and T. Kaya Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor Hum. Reprod., August 1, 2001; 16(8): 1732 - 1735. [Abstract] [Full Text] [PDF]
|
|