Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Chaouat, G.
Right arrow Articles by Frydman, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Chaouat, G.
Right arrow Articles by Frydman, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 10, No. suppl_2, pp. 55-58, 1995
© 1995 European Society of Human Reproduction and Embryology

Immuno–endocrine interactions in early pregnancy

Gérard Chaouat, Elisabeth Menu, Genevieve Delage, Jean Francois Moreau, Lakshmi Khrishnan1,2, Lin Hui2, Aines Assal Meliani3, Jacques Martal3, Raj Raghupathy1, Christophe Lelaidier, Catherine Bertrand, Sayonara Freitas, Edouard Hambartsumian, Thomas G. Wegmann2 and René Frydman

INSERM CJF 92-09 and Department of Obstetrics and Gynaecology, Hospital Béclére Clamart 92140 1 Department of Microbiology, Faculty of Medicine, Kuwait University PO Box 24 923, Safat, Kuwait 13110 2 University of Alberta, Department of Immunology Edmonton, Alberta, Canada TAG 2H7 3 Endocrinologie de I'Embryon 75350 Jouy en Josas Cedex, France

First we recall briefly the status of inflammatory cytokines in the early implantation period. We then describe the status of leukaemia inhibiting factor (LEF) production in an in-vitro, relatively short-term, human decidual explant culture system. We show that in most infertile women with recurrent implantation failure following successful in-vitro fertilization, LIF production is statistically much lower than normal. Other parameters of LIF production in vitro are summarized briefly, and the effects of RU486 are shown. The TH2 status of normal pregnancy is described, together with the production of TH2 cytokines by decidua and placenta. These cytokines are deficient in the CBAXDBA/2 model of murine spontaneous early pregnancy loss. The defect can be corrected by alloimmunization, and more importantly by the injection of tau interferon. The significance of these data for early pregnancy signalling is discussed.

Key words: cytokines/implantation/inhibiting factor/tau interferon/TH2


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.