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Human Reproduction, Vol. 11, No. 1, pp. 13-18, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Role of gonadotrophin releasing hormone baseline concentrations in the control of pituitary gonadotrophin and ovarian steroid secretion in the pseudopregnant rat

G.A. Schuiling1, N. Vaikhof and T.R. Koiter

Division of Reproductive Biology, Department of Obstetrics and Gynaecology, University of Groningen PO Box 30.001, 9700 RB Groningen, The Netherlands

Correspondence: 1To whom correspondence should be addressed

To study the effect of moderately elevated gonadotrophin releasing hormone (GnRH) baseline concentrations during the luteal and the follicular phase, pseudopregnant rats were infused s.c with GnRH at several doses for 5 days. These rats were also treated with oestradiol or sham-treated during the last 3 days of GnRH treatment GnRH infusions started on day 7 or day 3 of the luteal phase of the ovulatory cycle; in the rat, the luteal phase or pseudopregnancy lasts about 10 days. Luteinizing hormone (LH) and follicle stimulating hormone (FSH) responses were induced by i.v. injection of GnRH on day 12 (after expected luteolysis) or on day 8 (before expected luteolysis). In normal rats the LH and FSH responses induced by GnRH on day 12 were higher than on day 8 (~160 and ~50% respectively). In GnRH-infused rats the LH and FSH responses were not increased. In these rats the luteal phase was extended (the plasma progesterone concentrations remained high) and the onset of the follicular phase was postponed (plasma oestrogen concentrations did not increase). Oestradiol increased the day 12 LH and FSH responses; this effect of oestradiol was suppressed by GnRH infusion. On day 8, exogenous oestradiol also increased the LH and FSH responses, but again the effect of oestradiol was suppressed when the animals were concomitantly infused with GnRH. These data may suggest that in the rat, GnRH baseline concentrations participate in the neuroendocrine system controlling gonadotrophin secretion and hence the ovulatory cycle.

Key words: GnRH baseline concentrations/GnRH responsiveness/oestradiol/ovulatory cycle/pseudopregnancy


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G.A. Schuiling, N. Valkhof, and T.R. Koiter
FSH inhibits the augmentation by oestradiol of the pituitary responsiveness to GnRH in the female rat
Hum. Reprod., January 1, 1999; 14(1): 21 - 26.
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