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Human Reproduction, Vol. 11, No. 10, pp. 2127-2129, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Infertility: OPINION: Mimicking the high levels of activity of a large in-vitro fertilization unit leads to early success at the commencement of an in-vitro fertilization and embryo transfer programme

P.E. Egbase1,2, M. Al-Sharhan1, M. Al-Mutawa1, S. Al-Othman1 and J.G. Grudzinskas2,3

1IVF Centre, Maternity Hospital Kuwait 2Academic Unit of Obstetrics and Gynaecology, The Royal London Hospital London El IBB, UK

Correspondence: 3To whom correspondence should be addressed

Infertile couples seeking treatment will endeavour to obtain the-highest standards of care at a conveniently located centre. The success rates of a centre would also be an important concern. The busier in-vitro fertilization (IVF) units (>400 cycles per year) have substantially higher pregnancy rates than those carrying out <300 cycles per year. We report our experiences at the IVF Centre, Maternity Hospital, Kuwait of mimicking the high level of activity of a large IVF unit. Infertile couples were treated in groups of 30–35 every 4–6 weeks. Patients in each group had menstrual cycles synchronized to their luteal phase using progestogens. Thereafter they were down-regulated with gonadotrophin-releasing hormone agonist (long protocol). Oocyte retrieval and embryology activities were concentrated and completed in 7–10 days in each group. This episodic high level of activity was aimed at mimicking that of a busy large IVF centre, although continuous in the latter. The overall results in terms of fertilization, cleavage, implantation and clinical pregnancy rates were similar to those obtained in large IVF units. The clinical pregnancy rate per cycle was 25.8–39.1% in IVF and 46.1% in intracytoplasmic sperm injection.

Key words: IVF/ICSI/groups/success


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