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Human Reproduction, Vol. 11, No. 10, pp. 2208-2210, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Ovary and ovulation: Insulin-like growth factor binding protein-3 (IGFBP-3) serum concentrations and ovarian responsiveness in in-vitro fertilization

B. Salobir1, J. Prezelj1,4, H. Meden-Vrtovec2, A. Kocijancic1 and J. Osredkar3

1Department of Endocrinology Ljubljana, Slovenia 2Department of Obstetrics Gynaecology, Medical Centre Ljubljana, Slovenia 3Institute of Clinical Chemistry and Clinical Biochemistry Ljubljana, Slovenia

Correspondence: 4To whom correspondence should be addressed at: Zaloöka 7, 1105 Ljubljana, Slovenia

The growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis seems to play an important role in ovarian responsiveness. Recently IGF binding protein-3 (IGFBP-3) serum concentrations have been reported to be a good marker of GH/IGF-I axis activity. In view of this finding, we measured IGFBP-3 serum concentrations in 29 women undergoing in-vitro fertilization. We found a significant correlation among IGFBP-3 serum concentrations and markers of ovarian stimulation including efficacy index, serum oestradiol concentrations and the number of follicles on the day of human choriomc gonadotrophin (HCG) administration. The results of our study add additional evidence to the importance of the GH/IGF-I system in regulating ovarian responsiveness to gonadotrophin stimulation.

Key words: IGFBP-3/IVF/ovarian responsiveness


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