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Human Reproduction, Vol. 11, No. 10, pp. 2291-2297, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Pregnancy: Luteinizing hormone receptor in the human corpus luteum: lack of down-regulation during maternal recognition of pregnancy

W.C. Duncan1,3, A.S. McNeilly1, H.M. Fraser1 and P.J. Illingworth2

1MRC Reproductive Biology Unit, Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW, UK 2Department of Obstetrics and Gynaecology, University of Sydney, Westmead Hospital Sydney, NSW 2145, Australia

Correspondence: 3To whom correspondence should be addressed

Luteal progesterone production is dependent on luteinizing hormone (LH) from the pituitary gland. Despite continuing LH secretion, the human corpus luteum undergoes functional luteolysis unless it is ‘rescued’ by human chorionic gonadotrophin (HCG), produced by the implanting blastocyst. As LH and HCG act through a common receptor, this study sought to determine the expression of the LH/ HCG receptor in the corpus luteum during maternal recognition of pregnancy. Corpora lutea were collected at hysterectomy from women in the normal luteal phase and after luteal ‘rescue’ with exogenous HCG. In each case the corpus luteum was classified according to the date of the LH surge measured in daily urine samples. The expression of the LH receptor was investigated by Northern blotting, in-situ hybridization and in-situ ligand binding. LH receptor mRNA and ligand binding activity were detected in corpora lutea from all stages of the luteal phase. LH receptor expression and binding were maintained during maternal recognition of pregnancy in the presence of exponentially increasing HCG concentrations. These data show that the LH receptor is maintained throughout the functional life-span of the human corpus luteum and is not down-regulated during maternal recognition of pregnancy.

Key words: corpus luteum/human chononic gonadotrophin/luteinizing hormone/pregnancy/receptor


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