Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lanzone, A.
Right arrow Articles by Mancuso, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lanzone, A.
Right arrow Articles by Mancuso, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 11, No. 11, pp. 2382-2386, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Preconceptional and gestational evaluation of insulin secretion in patients with polycystic ovary syndrome

A. Lanzone1, A.M. Fulghesu, F. Cucinelli, M. Guido, V. Pavone, A. Caruso and S. Mancuso2

Institute of Obstetrics and Gynecology, Catholic University of Sacred Heart L.F. Vito 1, 00168 Rome 1OASI Institute of Research Troina, Italy

Correspondence: 2To whom correspondence should be addressed

The relationship between insulinaemia and obesity and glucose tolerance and the impact of pregnancy as risk factor for carbohydrate abnormalities were investigated in 91 consecutive patients with polycystic ovary syndrome (PCOS) aged 26–32 years. Fifteen normoglycaemic patients became pregnant within 6 months of the pregestational study using pharmacological induction of ovulation. Plasma concentrations of insulin and glucose after an oral glucose tolerance test (OGTT) were determined by immunoradiometric assay and glucose oxidase technique respectively. OGTT patients were classified according to their response as normoinsulinaemic (n = 46) or hyperinsulinaemic (n = 45). Impairment of glucose metabolism occurred in 12.1% (n = 11, 10 obese and one lean) of all PCOS subjects. Based on insulin secretion, 6.5% of normoinsulinaemic and 133% of hyperinsulinaemic patients had an impaired glucose tolerance and 23 and 2.2% respectively a noninsulin-dependent diabetes mellitus. Obese patients had higher values for area under the curve for insulin response to OGTT (I-AUC values) than lean patients, and the percentage above ideal body weight was greater in hyperinsulinaemic than in normoinsulinaemic patients. All hyperinsulinaemic (7/15) subjects who became pregnant developed an impairment of glucose metabolism during pregnancy. It is concluded that the PCOS population was at higher risk of developing carbohydrate abnormalities than the normal population of a similar reproductive age. Furthermore, those with abnormal insulin secretion at the pregestational stage may, during pregnancy, develop an impaired gestational glucose tolerance or gestational diabetes.

Key words: androgens/diabetes/insulin/obesity/pregnancy/PCOS


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. Vambergue, C. Lautier, A.S. Valat, C. Cortet-Rudelli, F. Grigorescu, and D. Dewailly
Follow-up study of two sisters with type A syndrome of severe insulin resistance gives a new insight into PCOS pathogenesis in relation to puberty and pregnancy outcome: a case report
Hum. Reprod., May 1, 2006; 21(5): 1274 - 1278.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.J. Glueck, N. Goldenberg, P. Wang, M. Loftspring, and A. Sherman
Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy
Hum. Reprod., March 1, 2004; 19(3): 510 - 521.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. Haakova, D. Cibula, K. Rezabek, M. Hill, M. Fanta, and J. Zivny
Pregnancy outcome in women with PCOS and in controls matched by age and weight
Hum. Reprod., July 1, 2003; 18(7): 1438 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Sir-Petermann, M. Maliqueo, B. Angel, H.E. Lara, F. Perez-Bravo, and S.E. Recabarren
Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization
Hum. Reprod., October 1, 2002; 17(10): 2573 - 2579.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. M. Koivunen, J. Juutinen, I. Vauhkonen, L. C. Morin-Papunen, A. Ruokonen, and J. S. Tapanainen
Metabolic and Steroidogenic Alterations Related to Increased Frequency of Polycystic Ovaries in Women with a History of Gestational Diabetes
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2591 - 2599.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Mikola, V. Hiilesmaa, M. Halttunen, L. Suhonen, and A. Tiitinen
Obstetric outcome in women with polycystic ovarian syndrome
Hum. Reprod., February 1, 2001; 16(2): 226 - 229.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.