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Human Reproduction, Vol. 11, No. 11, pp. 2405-2407, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Normal serum uric acid concentrations in women with polycystic ovary syndrome

L. Anttila1,4, J. Rouru2, T. Penttilä1 and K. Irjala3

1Department of Obstetrics and Gynecology, Turku University Central Hospital Kiinamyllynkatu 4-8 2Department of Pharmacology and Clinical Pharmacology, University of Turku 3Department of Clinical Chemistry, Turku University Central Hospital SF-20520 Turku, Finland

Correspondence: 4To whom correspondence should be addressed

Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Several biochemical and clinical features of polycystic ovary syndrome (PCOS) resemble those of metabolic syndrome: women with PCOS are often obese; they are also at increased risk for the development of coronary artery disease, hypertension and diabetes mellitus. The objective of the present study was to analyse the usefulness of serum uric acid measurement in screening for the metabolic syndrome in women with PCOS. For that purpose serum concentrations of uric acid, insulin and triglycerides were measured in 38 women with PCOS and 20 weight-matched control women with regular menstrual cycles. No differences were found in the uric acid concentrations between the PCOS and control groups. The mean concentrations of triglycerides and fasting insulin were higher in the women with PCOS than in the healthy controls. Serum uric acid concentrations were inversely related to serum hormone-binding globulin (SHBG) concentrations, and positively with body mass index (BMI), insulin concentrations and testosterone:SHBG ratio in the PCOS group. Our results suggest that measurement of serum uric acid does not provide new means for identification of metabolic syndrome in patients with PCOS.

Key words: nsulin resistance/metabolic syndrome/polycystic ovary syndrome/serum uric acid


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M. Luque-Ramirez, F. Alvarez-Blasco, M. G. Uriol Rivera, and H. F. Escobar-Morreale
Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin
Hum. Reprod., July 1, 2008; 23(7): 1594 - 1601.
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