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Human Reproduction, Vol. 11, No. 12, pp. 2645-2647, 1996
© 1996 European Society of Human Reproduction and Embryology

case-report

Andrology: Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved semen from a man with testicular cancer

Shee-Uan Chen, Hong-Nerng Ho, Hsin-Fu Chen, Su-Cheng Huang, Tzu-Yao Lee and Yu-Shih Yang1

College of Medicine and the Hospital, National Taiwan University Taipei, Taiwan

Correspondence: 1To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan

A successful pregnancy was achieved by intracytoplasmic sperm injection (ICSI) using cryopreserved semen from a man with testicular cancer. He was a victim of right testicular seminoma, and was azoospermic after right orchidectomy and radiotherapy. The wife had had three successive failures of intrauterine insemination (IUI) using semen that was cryopreserved before radiotherapy. The couple then underwent in-vitro fertilization (IVF) treatment ICSI was performed because the sperm motility was extremely poor after thawing. Eight of 12 injected oocytes had normal fertilization and embryo cleavage. After replacement of four embryos, a singleton pregnancy developed. She delivered a healthy male baby at 39 weeks gestation. In addition to IUI and IVF, ICSI further provides male patients with cancer an unproved chance of fathering a child. Any men diagnosed with cancer who have not yet finished their families should have their spermatozoa frozen before treatment, regardless of its quality.

Key words: cryopreserved semen/intracytoplasmic sperm injec-tion/testicular cancer


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