Human Reproduction, Vol. 11, No. 3, pp. 486-489, 1996
© 1996 European Society of Human Reproduction and Embryology
Evaluating ovarian reserve: follicle stimulating hormone and oestradiol variability during cycle days 2-5
1 Thomas Jefferson University School of Medicine, Department of Obstetrics and Gynecology 815 Locust Street, Philadelphia, Pennsylvania 19107–5507, USA 2 Pennsylvania Hospital, Department of Obstetrics and Gynecology 815 Locust Street, Philadelphia, Pennsylvania 19107–5507, USA 3 Philadelphia Fertility Institute 815 Locust Street, Philadelphia, Pennsylvania 19107–5507, USA
Correspondence: 4To whom correspondence should be addressed
A prospective measurement of follicle stimulating hormone (FSH) and oestradiol between cycle days 2 and 5 was conducted to investigate the intra- and inter-cycle variability in a healthy population of women with regular menstrual intervals. Daily serum samples were obtained from 44 women for a total of 66 cycles on cycle days 2, 3, 4 and 5. FSH concentrations were consistent on all cycle days measured. Oestradiol concentrations on cycle day 2 were not different from cycle day 3, but concentrations on cycle day 4 and cycle day 5 were statistically different from both cycle day 2 and cycle day 3 by analysis of variance (P < 0.05). Evaluation of functional ovarian reserve by cycle day 3 FSH measurement has become the standard in most assisted reproductive technology programmes. The recent change in FSH standardization coupled with the inflexibility of cycle day 3 testing has led to a re-evaluation of testing protocols. Cycle day 3 appears to have emerged as a dictum because most ovulation induction protocols are initiated on cycle day 3, 4 or 5. Flexibility of sampling day can be introduced as suggested by these results. The additional information ascertained from oestradiol testing as applied to evaluation of ovarian reserve warrants further investigation.
Key words: follicle stimulating honnone/oestradiol/ovarian reserve/reproductive potential
Submitted on September 11, 1995; accepted on January 2, 1996.
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