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Human Reproduction, Vol. 11, No. 4, pp. 737-740, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Ovarian activity and vaginal bleeding patterns with a desogestrel-only preparation at three different doses

C. Rice1, S. Killick1,4, D. Hickling2 and H.Coelingh Bennink3

1University of Hull, Department of Obstetrics and Gynaecology, the Princess Royal Hospital Saltshouse Road, Hull, HU8 9HE 2Withington Hospital Withington, Manchester, UK 3Medical R&D Unit, NV Organon PO Box 20, 5340 BH Oss, The Netherlands

Correspondence: 4To whom correspondence should be addressed

A randomized, double-blind, group-comparative study was performed over a 6 month period to compare ovarian suppression and vaginal bleeding during the use of three oral contraceptives containing doses of 30, 50 or 75 µg desogestrel. A total of 44 female volunteers with regular cycles and established ovulation by ultrasonography were recruited from an out-patient clinic hi a university hospital and asked to participate in the study. Ultrasonography and serum oestradiol and progesterone measurements were performed during two assessment periods. The 75 µg dose showed complete suppression of ovulation and a more acceptable bleeding pattern than the lower doses. The 75 jig dose of desogestrel is the most promising dose for the development of a new progestogen-only oral contraceptive agent.

Key words: desogestrel/ovarian activity/progestogen-only oral contraceptives


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A.M. van Heusden, S.R. Killick, H.J.T.C. Bennink, and B.C.J.M. Fauser
Single monthly administration of the anti-progestagen Org 31710 in users of the 75 {micro}g desogestrel progestagen-only pill: effects on pituitary-ovarian activity
Hum. Reprod., March 1, 2000; 15(3): 629 - 636.
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