Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kaayk, E. M.
Right arrow Articles by van Gemert, M. J.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaayk, E. M.
Right arrow Articles by van Gemert, M. J.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 11, No. 4, pp. 808-813, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Transvaginal interstitial laser treatment of the ovary: a feasibility study in cows

Eugenie M. Kaayk1,2,5, Maarten C. Pieterse4, Johan F. Beek1, Fulco van der Veen2, Fibo J.W.ten Kate3, Frits B. Lammes2 and Martin J.C. van Gemert1

1Laser Centre Meibergdreef 9, 1105 AZ Amsterdam 2Divisions of Gynaecology and Reproductive Endocrinology Meibergdreef 9, 1105 AZ Amsterdam 3Pathology, Academic Medical Centre Amsterdam 4Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, University of Utrecht Utrecht, The Netherlands

Correspondence: 5To whom correspondence should be addressed

In 12 cows, transvaginal interstitial laser treatment (TILT) of the ovaries was performed using a neodynium: yttrium aluminium-garnet laser to investigate the feasibility of a new treatment approach for clomiphene-resistant patients with chronic hyperandrogenic anovulation. Powers of 1 and 2 W during 5 min of exposure were used. Sonographic changes of thermal damage during TILT, the extent and healing of the lesions by light microscopy and ultrasound during a 3 month follow-up and adhesion formation were studied. During laser irradiation, a hyperechogenic zone developed around the fibre tip, with a mean ± SD diameter of 4.4 ± 2.0 mm at 1 W and 6.9 ± 1.5 mm at 2 W. The mean diameters of the histological lesions 2 days after treatment were 7.3 ± 2.5 mm at 1 W and 13.0 ± 2.1 mm at 2 W. During follow-up, the mean diameter of both the histologically and the sonographically assessed lesions decreased, although transvaginal sonography (TVS) systematically and significantly underestimated the thermal damage. Lesions healed by fibrosis and no adhesions were present TILT of the ovaries in cows is easy to perform and produces central or subcapsular necrosis without adhesions. TVS gives an indication of thermal damage but underestimates the extent of tissue damage in cow ovaries. Obviously, this study does not allow conclusions to be drawn concerning its safety and efficacy in man.

Key words: adhesion formation/chronic hyperandrogenic anovulation/Nd; YAG laser/transvaginal sonography


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.