Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Nezhat, C. H.
Right arrow Articles by Nezhat, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nezhat, C. H.
Right arrow Articles by Nezhat, C. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 11, No. 4, pp. 874-877, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Is hormonal treatment efficacious in the management of ovarian cysts in women with histories of endometriosis?

Ceana H. Nezhat1,2, Farr Nezhat1,2, Soheila Borhan3, Daniel S. Seidman2 and Camran R. Nezhat1,2,4,5

1Department of Obstetrics and Gynecology, Mercer University School of Medicine Macon, GA 2Department of Obstetrics and Gynecology, Stanford University School of Medicine Stanford, CA 3Department of Obstetrics and Gynecology, Louisiana State University New Orleans, LA 4Department of Surgery, Stanford University School of Medicine Stanford, CA, USA

Correspondence: 5To whom correspondence should be addressed at: 900 Welch Road, Suite 405. Palo Alto, California 94304, USA

In a controlled, randomized study, we evaluated the effectiveness of various hormonal regimens in treating 70 women (mean age 34.7 ± 5.7 years) who had unilateral or bilateral ovarian cysts presumed to be physiological (functional) and a history of endometriosis. The patients were assigned randomly to one of the following groups: group I (control), no treatment; group II, oral contraceptives (35 µg ethinyl oestradiol and 1 mg norethindrone); group III, oral contraceptives (50 µg ethinyl oestradiol and 1 mg norethindrone); group IV, danazol 800 mg/day. Serum CA-125 concentrations were measured in 32 women. All medications were taken continuously for 6 weeks. Subjects were re-evaluated by pelvic examination and transvaginal ultrasound. Those with persistent cysts were offered diagnostic and possible operative laparoscopy. As 11 patients did not complete the study and five did not follow-up, the final study population comprised 54 women. At 6 weeks follow-up, complete resolution of cysts was found in: group I, 12 out of 18 (66.7%); group II, five out of nine (55.6%); group III, eight out of 14 (57.1%); and group IV, seven out of 13 (53.9%). Two of the 22 women with persistent cysts opted for 6 weeks further medical therapy and achieved complete resolution; 19 underwent laparoscopy, and one was lost to follow-up. All laparoscopic findings revealed benign masses. We found no statistically significant effect when hormonal treatment was compared with expectant management There was no correlation between serum CA-125 concentrations and the persistence or resolution of cysts.

Key words: endometriosis/hormonal suppressive therapy/physiological ovarian cyst


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.