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Human Reproduction, Vol. 11, No. 5, pp. 968-974, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Adipocyte insulin action during the normal menstrual cycle

Philippa J. Marsden1,3, Alison Murdoch1 and Roy Taylor2

1Centre for Reproductive Medicine, Royal Victoria Infirmary Queen Victoria Road, Newcastle upon Tyne NE1 4LP 2Department of Medicine, University of Newcastle upon Tyne UK

Correspondence: 3To whom correspondence should be addressed

The relationship between the menstrual cycle and insulin sensitivity is unclear. The aim of this study was to investigate insulin sensitivity during the normal menstrual cycle using the physiological insulin target organ adipose tissue. A total of 23 normal healthy volunteers were studied, nine of whom were in the follicular phase, and 14 of whom were age and body mass index-matched and in the luteal phase of the menstrual cycle. Adipocyte insulin receptor binding was measured and adipocyte insulin action was assessed by measuring initial rates of 3–0-methylglucose uptake and by inhibition of lipolysis. The maximum specific insulin receptor binding was significantly higher in subjects studied during the follicular phase of the menstrual cycle compared to subjects studied during the luteal phase (1.81 ± 0.13 versus 136 ± 0.15% per 10 cm2 cell surface, P < 0.05). Maximum rates of 3–0-methylglucose transport were 1.70 ± 0.22 versus 1.75 ± 0.22 pmol/10 cm2/5 s in the follicular and luteal phase respectively and were not significantly different between the two groups. The maximum percentage lipolysis inhibition observed was 42.5 ± 7.5% in the follicular phase and 39.9 ± 7.4% in the luteal phase (not significant). This study demonstrated that there is a reduction in insulin receptor binding in the luteal phase of the normal ovulatory menstrual cycle. The post-receptor action of insulin is not affected between the two phases of the menstrual cycle.

Key words: adipose tissue/insulin action/menstrual cycle


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