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Human Reproduction, Vol. 11, No. 6, pp. 1177-1179, 1996
© 1996 European Society of Human Reproduction and Embryology

case-report

Severe ovarian hyperstimulation syndrome despite low plasma oestrogen concentrations in a hypogonadotrophic, hypogonadal patient

Tally Levy, Raoul Orvieto, Roy Homburg, Dan Peleg, Arie Dekel and Zion Ben-Rafael1

Fertility Unit, Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tikva 49372, Affiliated to the Sackler School of Medicine Tel Aviv University, Israel

Correspondence: 1To whom correspondence should be addressed

Ovarian hyperstimulation syndrome (OHSS) is the most serious, life-threatening, iatrogenic complication of ovuia-tion induction. The importance of excessive oestradiol concentrations on the day of human chorionic gonadotro-phin (HCG) administration as a predictor and factor in the pathophysiology of OHSS has been extensively studied and discussed. We present the case report of a woman with hypogonadotrophic hypogonadism who developed severe OHSS during ovulation induction with urinary human follicle stimulating hormone (FSH) and HCG in the presence of low circulating oestradiol concentrations. The implication of FSH treatment and complications in hypogonadotrophic hypogonadal patients, and the role of pre-ovulatory oestradiol concentrations in the prediction of OHSS, are discussed.

Key words: hypogonadotrophic hypogonadism/oestradiol con-centration/OHSS/prediction


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