Human Reproduction, Vol. 11, No. 6, pp. 1185-1189, 1996
© 1996 European Society of Human Reproduction and Embryology
research-article |
Antiphospholipid antibodies in women having in-vitro fertilization
1Nuffield Department of Obstetrics and Gynaecology, University of Oxford, The Women's Centre, Oxford Radcliffe Hospital Oxford OX3 9DU 2Department of Immunology, University of Liverpool Livelpool, L69 3BX, UK 3Department of Obstetrics and Gynaecology, National Women's Hospital, University of Auckland New Zealand
Correspondence: 4To whom correspondence should be addressed
Antiphospholipid antibodies have an established association with pregnancy complications such as recurrent miscarriage, growth retardation, placental abruption and stillbirth but their mechanism of action is unclear. We have investigated whether antiphospholipid antibodies occur more frequently in women having in-vitro fertilization (IVF) and whether their presence is associated with the likelihood of failed implantation. We studied 240 women undergoing IVF treatment who were <38 years and had attempted fewer than three previous IVF cycles. Antiphos-pholipid antibodies (anticardiolipin and antiphosphatidyl serine immunoglobulin G and immunoglobulin M) were present in 36 out of 240 (15%) of the study population and were not associated with a failed IVF cycle or miscarriage. There was no association between the cause of infertility and the presence of antiphospholipid antibodies. Antiphos-pholipid antibodies were not detected more frequently in women with previous attempts at IVF compared with women having their first cycle, indicating that the high incidence of these antibodies is not due to the IVF treatment. There was a strong association between the presence of antiphospholipid antibodies and intrauterine growth retardation in singleton pregnancies (P<0.005). We recommend routine screening for the presence of antiphos-pholipid antibodies in women having IVF in order to identify those pregnancies at increased risk of intrauterine growth retardation.
Key words: anticardiolipin antibodies/antiphospholipid anti-bodies/growth retardation/implantation/IVF
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