Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (76)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Abramov, Y.
Right arrow Articles by Barak, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abramov, Y.
Right arrow Articles by Barak, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 11, No. 7, pp. 1381-1386, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Plasma inflammatory cytokines correlate to the ovarian hyperstimulation syndrome

Y. Abramov1, J.G. Schenker, A. Lewin, S. Friedler, B. Nisman and V. Barak

Department of Obstetrics and Gynecology, and the Immunology Laboratory for Tumour Diagnosis, Oncology Department, The Hebrew University Hadassah Medical Center Em-Kerem, Jerusalem, Israel

Correspondence: 1To whom correspondence should be addressed at Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Em Kerem, PO Box 12000, Jerusalem il-91120, Israel

The objective of this study was to follow the kinetics of four inflammatory cytokines in the plasma and aseitic fluid of seven patients who developed severe ovarian hyperstimulation syndrome (OHSS) after induction of ovulation for in-vitro fertilization. Blood samples were obtained from these patients at three different times: upon hospitalization; when significant clinical improvement was evident; and after complete resolution. Samples were analysed for interleukin-1 (IL-i), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor {alpha} (TNF-{alpha}). Ascitic fluid was obtained by therapeutic paracentesis from all study patients during the active phase and analysed for these cytokines. Two control groups were available: the first Included 15 women undergoing controlled ovarian stimulation for in-vitro fertilization without developing OHSS, while the second consisted of 25 healthy women not undergoing ovulation induction or any other medical treatment. High concentrations of IL-1, IL-6, and TNF-{alpha} were detected in all individuals upon admission for severe OHSS. Concentrations dropped significantly along with clinical improvement, reaching normal values after complete resolution. A statistically significant correlation was found between plasma cytokine concentrations and certain biological char acteristics of the syndrome such as leukocytosis, increased haematocrit, and elevated plasma 17-{beta}-oestradiol concentrations. Ascitic fluid obtained from the study patients contained high IL-6 and IL concentrations, while other cytokines were unaltered. These results suggest close association between inflammatory cytokines and the pathophysiology of the ovarian hyperstimulation syndrome.

Key words: interleukin-1/interleukin-6/interleukin-8/ovarian hyperstimulation syndrome/tumour necrosis factor


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
K. Mouzat, F. Volat, S. Baron, G. Alves, A. J. C. Pommier, D. H. Volle, G. Marceau, A. DeHaze, P. Dechelotte, R. Duggavathi, et al.
Absence of Nuclear Receptors for Oxysterols Liver X Receptor Induces Ovarian Hyperstimulation Syndrome in Mice
Endocrinology, July 1, 2009; 150(7): 3369 - 3375.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
P. Aramwit, K. Pruksananonda, N. Kasettratat, and K. Jammeechai
Risk factors for ovarian hyperstimulation syndrome in Thai patients using gonadotropins for in vitro fertilization
Am. J. Health Syst. Pharm., June 15, 2008; 65(12): 1148 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S.-U. Chen, C.-H. Chou, H. Lee, C.-H. Ho, C.-W. Lin, and Y.-S. Yang
Lysophosphatidic Acid Up-Regulates Expression of Interleukin-8 and -6 in Granulosa-Lutein Cells through Its Receptors and Nuclear Factor-{kappa}B Dependent Pathways: Implications for Angiogenesis of Corpus Luteum and Ovarian Hyperstimulation Syndrome
J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 935 - 943.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Villasante, A. Pacheco, E. Pau, A. Ruiz, A. Pellicer, and J.A. Garcia-Velasco
Soluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome
Hum. Reprod., March 1, 2008; 23(3): 662 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
G. G. Gosman, H. I. Katcher, and R. S. Legro
Obesity and the role of gut and adipose hormones in female reproduction
Hum. Reprod. Update, September 1, 2006; 12(5): 585 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Babayof, E. J. Margalioth, M. Huleihel, A. Amash, E. Zylber-Haran, M. Gal, B. Brooks, T. Mimoni, and T. Eldar-Geva
Serum inhibin A, VEGF and TNF{alpha} levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial
Hum. Reprod., May 1, 2006; 21(5): 1260 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Kitajima, T. Endo, K. Nagasawa, K. Manase, H. Honnma, T. Baba, T. Hayashi, H. Chiba, N. Sawada, and T. Saito
Hyperstimulation and a Gonadotropin-Releasing Hormone Agonist Modulate Ovarian Vascular Permeability by Altering Expression of the Tight Junction Protein Claudin-5
Endocrinology, February 1, 2006; 147(2): 694 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Delbaere, G. Smits, O. Olatunbosun, R. Pierson, G. Vassart, and S. Costagliola
New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?
Hum. Reprod., March 1, 2004; 19(3): 486 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. Raziel, S. Friedler, M. Schachter, D. Strassburger, E. Mordechai, and R. Ron-El
Increased early pregnancy loss in IVF patients with severe ovarian hyperstimulation syndrome
Hum. Reprod., January 1, 2002; 17(1): 107 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.-D. Chen, H.-F. Chen, H.-F. Lu, S.-U. Chen, H.-N. Ho, and Y.-S. Yang
Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome
Hum. Reprod., May 1, 2000; 15(5): 1037 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.-D. Chen, M.-Y. Wu, H.-F. Chen, S.-U. Chen, H.-N. Ho, and Y.-S. Yang
Relationships of serum pro-inflammatory cytokines and vascular endothelial growth factor with liver dysfunction in severe ovarian hyperstimulation syndrome
Hum. Reprod., January 1, 2000; 15(1): 66 - 71.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
R. Orvieto and Z. Ben-Rafael
Ovarian Hyperstimulation Syndrome: A New Insight Into an Old Enigma
Reproductive Sciences, May 1, 1998; 5(3): 110 - 113.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.