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Human Reproduction, Vol. 11, No. 7, pp. 1403-1404, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Endocrinology: A ‘sweet’ indication for ovulation induction

Yoav Peled, David Rabinerson, Boris Kaplan, Linda Harel and Moshe Hod1

Department of Obstetrics and Gynecology, Rabin Medicai Center, Beilinson Campus, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel

Correspondence: 1To whom correspondence should be addressed at Department of Obstetrics and Gynecology, Rabin Medical Center, Bethnson Campus, Petah Tiqva 49100, Israel

In diabetic patients, euglycaemia at the thne of conception is crucial for the success of the pregnancy. In consideration of the difficulty in achieving and maintaining tight glycaemic control for long periods, we administered clomiphene citrate, which is usually indicated in cases of absent or infrequent ovulation, to enhance fecundability in 10 pregestational diabetic patients. All conceived within one to three cydes of the drug, and nine delivered healthy term babies after uneventful pregnancies; one aborted spontaneously in the eighth gestatlonal week. No effect of the drug on the diabetes was noted as based on measurements of glycosylated haemoglobin and fructosainine con centrations and the absence of changes in the patients' insulin requirements. In the light of these successful results, and in view the importance of euglycaemia at the beginning of diabetic pregnancies, we suggest a new ‘sweet’ indication for the use of clomiphene citrate.

Key words: clomiphene citrate/diabetes mellitus/ovulation induction/pregnancy


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