Skip Navigation

This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ubaldi, F.
Right arrow Articles by Devroey, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ubaldi, F.
Right arrow Articles by Devroey, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 11, No. 7, pp. 1405-1407, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Endocrinology: Subtle progesterone rise after the administration of the gonadotrophin-releasing hormone antagonist Cetrorelix in intracytoplasmic sperm injection cycles

Filippo Ubaldi1,3, Carola Albano1, Manfred Peukert2, Hilde Riethmüller-Winzen2, Michel Camus1, Johan Smitz1, André Van Steirteghem1 and Paul Devroey1

1Centre for Reproductive Medicine, Dutch-speaking Brussels Free University Brussels, Belgium 2ASTA-Medica AG, Frankfurt am Main, Germany

Correspondence: 1To whom correspondence should be addressed

In the present study, subtle serum progesterone rise (≥1.1 ng/ml) during the late follicular phase is reported, for the first time to our knowledge, in patients using a potent gonadotrophin-releasing hormone (GnRR) antagonist, Cetrorelix, in combination with human menopausal gonadotrophin (HMG) for ovarian stimulation prior to intracytoplasmic sperm injection (ICSI). In five out of 24 patients (20%) serum progesterone levels were≥1.1 ng/ml. The cycle characteristics of the patients were similar in both groups. No premature endogenous luteimzing hor mone (LH) surge occurred and the serum LH concentrations were constantly low during the follicular phase. The l7- oestradiol and follicle stimulating hormone (FSH) exposure were higher in cycles with premature luteinization. The greater oestradiol and FSH exposure confirm that one of the possible factors inducing subtle serum progesterone rise is the increased oestradiol and FSH induced LH receptivity in granulosa cells.

Key words: Cetrorelix/follicular phaselGnRH antagonist/ovarian stimulation/serum progesterone


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
E. Bosch
Comment on: Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. By Venetis et al (2007)
Hum. Reprod. Update, March 1, 2008; 14(2): 194 - 195.
[Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C.A. Venetis, E.M. Kolibianakis, E. Papanikolaou, J. Bontis, P. Devroey, and B.C. Tarlatzis
Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis
Hum. Reprod. Update, July 1, 2007; 13(4): 343 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F. Nawroth and M. Ludwig
What is the 'ideal' duration of progesterone supplementation before the transfer of cryopreserved-thawed embryos in estrogen/progesterone replacement protocols?
Hum. Reprod., May 1, 2005; 20(5): 1127 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.-L. Hwang, L.-W. Huang, B.-C. Hsieh, Y.-L. Tsai, S.-C. Huang, C.-Y. Chen, M.-L. Hsieh, P.-H. Chen, and Y.-H. Lin
Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles
Hum. Reprod., January 1, 2003; 18(1): 45 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Filicori, G.E. Cognigni, P. Pocognoli, C. Tabarelli, D. Spettoli, S. Taraborrelli, and W. Ciampaglia
Modulation of folliculogenesis and steroidogenesis in women by graded menotrophin administration
Hum. Reprod., August 1, 2002; 17(8): 2009 - 2015.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.