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Human Reproduction, Vol. 11, No. suppl_2, pp. 90-94, 1996
© 1996 European Society of Human Reproduction and Embryology

Progesterone receptor in Norplant® endometrium

Tseng M. Lau2, Julianto Witjaksono1 and Peter A. W. Rogers

1 Department of Obstetrics and Gynaecology, Reproductive Endocrinology Division, Faculty of Medicine, University of Indonesia Jakarta 10430, Indonesia Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre 246 Clayton Road, Clayton, Victoria 3168, Australia

Correspondence: 2To whom correspondence should be addressed

Endometrial progesterone receptor plays an important role in determining the biological activity of progestogens in fertility regulation. Studies during the normal menstrual cycle have shown that the concentrations of endometrial progesterone receptor and its mRNA vary in glandular epithelia but remain steady in stromal cells. There is general agreement between progesterone receptor mRNA and protein levels during the normal menstrual cycle. Norplant® endometrium had an increase in irnmnnoreactive progesterone receptor concentration but a reduction in progesterone receptor mRNA levels compared with controls. An immunohisto-chemical study, using the expression of the lysosomal protease cathepsin D as a marker for the functional status of progesterone receptors, failed to confirm the functionality of the receptors in Norplant endometrium. Together, these results suggest that (i) there is a differential sensitivity of glandular and stromal progesterone receptors to steroid regulation during the normal menstrual cycle; (ii) there appears to be a dissociation between the concentrations of progesterone receptor and its mRNA in Norplant endometrium; and (iii) there was significantly more progesterone receptor mRNA and lower plasma oestrogen concentrations hi Norplant subjects with amenorrhoea than with endometrial bleeding. The clinical significance of the differences in progesterone receptor mRNA levels and plasma oestrogen concentrations between the amenorrhoea group and the bleeding group requires further investigation.

Key words: endometrium/mRNA/Norplant/progesterone/receptor


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