Human Reproduction, Vol 12, 2108-2114, Copyright © 1997 by Oxford University Press
PK Manasco, DM Umbach, SM Muly, DC Godwin, A Negro-Vilar, MD Culler and LE Underwood
We measured luteinizing hormone (LH) and follicle stimulating hormone (FSH)
by immunofluorometric assays and alpha-inhibin by radioimmunoassay in serum
sampled every 10 min throughout the night (2100-0500 h) from 44 normal
girls. Mean overnight LH values rose log- linearly from a mean of 0.2 IU/l
in prepubertal girls to 3.0 IU/l in late pubertal girls. Log2 mean
overnight FSH rose rapidly through early puberty and then remained
constant; mean FSH rose from 1.0 IU/l in prepubertal girls to approximately
2.8 IU/l in Tanner III-V girls. Mean overnight inhibin increased through
puberty, rising from 151 ng/l in prepubertal girls to 432 ng/l in fully
pubescent girls. Within each of the first three Tanner stages, LH differed
approximately 100-fold between the smallest and largest mean concentrations
but differed <10- fold within stages IV or V. Such within-pubertal stage
variability was less pronounced for FSH, which differed approximately
16-fold among Tanner I subjects and 4-10-fold at later stages, and for
inhibin, which varied approximately 4-fold within each Tanner stage. The
frequency of LH pulses during overnight sampling increased significantly
during puberty, but the frequency of FSH and inhibin pulses remained
constant. We compared the results from girls to those from 50 normal boys
[Manasco et al. (1995) J. Clin. Endocrinol. Metab., 80, 20462052]. At each
pubertal stage, girls had approximately the same mean overnight LH values
as boys; girls had higher mean overnight FSH, particularly during Tanner
stages II-IV; and boys had mean overnight alpha-inhibin immunoreactivity
approximately 1.5 times that of girls at each pubertal stage. Still,
hormone concentrations for individuals of both sexes intergraded at each
pubertal stage.
ARTICLES
Ontogeny of gonadotrophin and inhibin secretion in normal girls through puberty based on overnight serial sampling and a comparison with normal boys
Laboratory of Molecular and Integrative Neurosciences, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709-2233, USA.
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