Human Reproduction, Vol 12, 2200-2207, Copyright © 1997 by Oxford University Press
RW Kelly and HO Critchley
The immunosuppressive effect of human seminal plasma and its implications
for sperm survival are reviewed. Human semen contains high concentrations
of prostaglandins that can effect a cytokine-mediated switch away from a
cell-mediated immune response. This effect on antigen presenting cells
would induce a state of non-responsiveness to sperm antigens in the female
reproductive tract. It is postulated that the induction of anergy to sperm
antigen may be fundamental to the continuing fecundity of the individual.
However, although this immune system modulation will benefit the
spermatozoa, the response to infective agents present in semen will also be
affected, which may play a critical role in the aetiology and progress of
sexually transmitted disease.
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Immunomodulation by human seminal plasma: a benefit for spermatozoon and pathogen?
Medical Research Council Reproductive Biology Unit, University of Edinburgh Centre for Reproductive Biology, UK.
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