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Human Reproduction, Vol. 12, No. 11, pp. 2373-2375, 1997
© 1997 European Society of Human Reproduction and Embryology

Oral misoprostol for cervical priming in non-pregnant women

Suk Wai Ngai1, Yik Ming Chan, Ka Lai Liu and Pak Chung Ho

Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital Hong Kong

Correspondence: 1To whom correspondence should be addressed

Endometrial biopsy and hysteroscopy are important investigations in women presenting with abnormal vaginal bleeding. Endometrial biopsy is often performed as an outpatient procedure by endometrial aspiration. Difficulty in entering the internal cervical os may be encountered, especially in nulliparous women. The same problem may occur during hysteroscopy or dilatation and curettage. It is well known that use of a cervical priming agent is effective in reducing complications during cervical dilatation in pregnant women. However, its use in non-pregnant women is not well established. We compared oral misoprostol versus placebo for a cervical priming effect in non-pregnant women prior to hysteroscopy. The cumulative force required for cervical dilatation was significantly lower whereas the baseline cervical dilatation was significantly greater in the misoprostol group. We conclude that oral misoprostol is effective for pre-operative cervical dilatation in non-pregnant women.

Key words: cervical priming/non-pregnant women/oral misoprostol

Submitted on March 31, 1997; accepted on August 1, 1997.


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