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Human Reproduction, Vol 12, 2393-2398, Copyright © 1997 by Oxford University Press

ARTICLES

Lymphocytes of human term decidua decrease cell adhesion to a plastic substrate

AC Abadia-Molina, C Ruiz, A King, YW Loke and EG Olivares
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Granada, Spain.

Although human decidual lymphocytes have been widely studied, their function and possible interaction with trophoblast are still unclear. Here we show that whereas human early (EDL) and term (TDL) decidual lymphocytes were unable to kill human trophoblast by necrosis (assessed by the 51Cr-release assay) or apoptosis (DNA fragment assay), TDL but not EDL decreased trophoblast adhesion to a plastic substrate as determined by a [3H]thymidine assay. This effect, however, was not selective for trophoblast, as TDL also decreased the adhesion to plastic of human decidual stromal cells and HeLa cells. Our results suggest that TDL may play a role in placental detachment during parturition by decreasing trophoblast or decidual stromal cell adhesion.
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