Human Reproduction, Vol 12, 2603-2606, Copyright © 1997 by Oxford University Press
PE Egbase, M Makhseed, M Al Sharhan and JG Grudzinskas
Unilateral ovarian follicular aspiration 6-8 h prior to trigger
administration of human chorionic gonadotrophin (HCG) was performed or not
in 31 women at serious risk of ovarian hyperstimulation syndrome (OHSS)
after ovarian stimulation for in-vitro fertilization (IVF)- embryo transfer
or intracytoplasmic sperm injection (ICSI) in this prospective randomized
study. Unilateral follicular aspiration was performed in 16 women (group 1)
matched for age, indication for fertility treatment, and the amount and
duration of gonadotrophin exposure with 15 women not receiving aspiration
treatment (group 2). There was a statistically significantly (P < 0.001)
lower mean number of oocytes obtained from group 1 women (14.9 +/- 1.8 vs
22.6 +/- 2.4). The fertilization (53.2 +/- 2.6 vs 65.5 +/- 1.35%) and
embryonic cleavage (91.3 +/- 2.1 vs 90.2 +/- 1.75%) rates were similar in
both groups. OHSS occurred in women from both groups (group 1: 25% vs group
2: 33.3%) being severe OHSS in two women from group 1 and one from group 2.
We conclude that unilateral ovarian early follicular aspiration prior to
HCG trigger administration does not reduce the occurrence of severe OHSS in
women at risk.
ARTICLES
Timed unilateral ovarian follicular aspiration prior to administration of human chorionic gonadotrophin for the prevention of severe ovarian hyperstimulation syndrome in in-vitro fertilization: a prospective randomized study
IVF Centre, Maternity Hospital, Kuwait.
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