Human Reproduction, Vol 12, 2607-2613, Copyright © 1997 by Oxford University Press
DD Baird, AJ Wilcox, CR Weinberg, F Kamel, DR McConnaughey, PI Musey and DC Collins
We compared daily urinary concentrations of oestrogen and progesterone
metabolites in paired menstrual cycles (conception and non-conception) from
32 women. Volunteers with no known fertility problems were enrolled in the
study at the time they began trying to become pregnant. They collected
first-morning urine specimens and kept daily records of menstrual bleeding
and sexual intercourse for 6 months or until they became clinically
pregnant. Intercourse in non-conception cycles was close to the time of
ovulation so that failure to conceive was caused by factors other than
poorly timed intercourse. Compared with non- conception cycles, conception
cycles had a steeper early luteal rise in progesterone and higher
mid-luteal oestrogen and progesterone concentrations. These hormonal
characteristics may be markers of better quality cycles, but because all
these differences were in the luteal phase, we cannot rule out the
possibility that the preimplantation embryo had stimulated early increases
in steroid production. We propose an analysis strategy that could help
support or refute the importance of preimplantation embryonic signalling,
but our small sample size limits our own conclusions about this mechanism.
ARTICLES
Preimplantation hormonal differences between the conception and non- conception menstrual cycles of 32 normal women
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
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