Human Reproduction, Vol 12, 2635-2640, Copyright © 1997 by Oxford University Press
M Montag, K van der Ven, S Ved, A Schmutzler, G Prietl, D Krebs, B Peschka, G Schwanitz, P Albers, G Haidl and H van der Ven
This paper reports on results of intracytoplasmic sperm injection (ICSI) in
patients in whom constitutional or secondary chromosome aberrations were
detected in the male and/or female partner. Out of 434 couples treated by
ICSI (590 cycles), 16 couples (3.7%) were affected by constitutional
chromosome aberrations and 96 (22.1%) by secondary chromosome aberrations.
Constitutional chromosome aberrations were found in eight male and eight
female patients. Couples with the aberration in the male showed
significantly lower fertilization, implantation and pregnancy rates (P <
0.05). The occurrence of female constitutional chromosome aberrations led
to lower fertilization rates but implantation and pregnancy rates were
similar to a control group; however, a higher abortion rate was noted. In
the group with secondary chromosome aberrations, 22 males and 59 females
carried an abnormality and in 15 couples, both partners. Compared to the
remaining (unaffected) 322 couples, fertilization and embryo transfer rates
were reduced but implantation rates and pregnancy rates were not different.
In all couples where an abortion occurred, mainly parental autosomal
aberrations were involved (six out of eight). Our retrospective analysis
shows that an unexpectedly high number of infertile couples in an ICSI
programme are affected by chromosome aberrations, which in turn may explain
the reduced fertilization rates observed in this subgroup of patients.
ARTICLES
Success of intracytoplasmic sperm injection in couples with male and/or female chromosome aberrations
Department of Endocrinology and Reproductive Medicine, University of Bonn, Germany.
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