Human Reproduction, Vol 12, 301-305, Copyright © 1997 by Oxford University Press
E Ekerhovd, M Brannstrom, M Alexandersson and A Norstrom
Endogenously produced nitric oxide (NO) induces relaxation in smooth muscle
in various organs. The purpose of this study was to investigate whether a
NO-mediated relaxation system exists in the human Fallopian tube. To study
contractility, the isthmic portion of the tube was obtained from 23 fertile
women during operations due to benign non- tubal diseases. Tubal smooth
muscle strips were mounted in tissue chambers containing HEPES buffer and
connected to a Grass transducer for the isometric registration of
contractile activity. By adding L- arginine (the substrate for NO
synthesis) or N-nitro-L-arginine methyl ester (L-NAME; an inhibitor of NO
synthesis) to the tissue chambers, changes in tubal contractility were
monitored. The addition of L-NAME caused increased tubal contractility,
while L-arginine, after an initial transient increase in tonus, caused
relaxation of the strips. Using immunohistochemistry, NO synthase, the
enzyme that catalyses the production of NO from L-arginine, was identified
in tubal tissue cells. These results indicate that a NO-dependent
relaxation system exists in the Fallopian tube and that NO may play a role
as a mediator of tubal contractility.
ARTICLES
Evidence for nitric oxide mediation of contractile activity in isolated strips of the human Fallopian tube
Department of Obstetrics and Gynecology, University of Goteborg, Sweden.
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