Human Reproduction, Vol 12, 441-445, Copyright © 1997 by Oxford University Press
K Takamatsu, M Kasuga, M Nakano, Y Udagawa, Y Yoshimura and S Nozawa
Changes in CA602 and CA546, two carbohydrate-related antigens newly
established in our institute, were evaluated during the course of in- vitro
fertilization and embryo transfer. The concentration of CA602, an antigen
with characteristics similar to those of CA125, did not change
substantially until embryo transfer. In patients with clinical evidence of
ovarian hyperstimulation syndrome (OHSS), a significant increase in serum
concentrations of CA602 was observed 10 days after embryo transfer (P <
0.01). There were no significant changes in the patients without OHSS. A
significant elevation of oestradiol concentration in OHSS patients was also
observed, with the variation before oocyte retrieval being greater than
that seen with CA602. The concentration of CA546, which had lower
false-positive rates in benign disease, did not differ significantly in the
OHSS and non-OHSS patients. Our data demonstrate that serum concentrations
of CA602 are increased even in early stages of OHSS, and suggest a possible
role for this antigen as a marker for OHSS.
ARTICLES
Changes in CA602 and CA546 concentrations in patients during in-vitro fertilization and embryo transfer, and ovarian hyperstimulation syndrome
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
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