Human Reproduction, Vol 12, 474-477, Copyright © 1997 by Oxford University Press
K Sengoku, K Tamate, N Takuma, T Yoshida, K Goishi and M Ishikawa
The present study was designed to compare the cycle characteristics of
in-vitro fertilization (IVF) and the chromosomal normality of oocytes in
patients with polycystic ovarian syndrome (PCOS) with those of patients
with tubal factor infertility. In all, 28 cycles of 24 PCOS patients and 55
cycles of 31 patients with tubal factor infertility (control) were
investigated. Although a significantly greater number of oocytes were
retrieved from PCOS patients (mean +/- SD: 15.6 +/- 6.4 versus 9.0 +/- 4.0,
PCOS versus control group, P < 0.05), the percentage of fertilized
oocytes was significantly lower in the PCOS group compared with controls
(40.1 versus 73.8%, P < 0.01). The pregnancy rate per embryo transfer
did not differ between the two groups. Cytogenetic analysis was performed
on 74 oocytes from PCOS patients and 73 oocytes from control patients. In
the PCOS group, 10 of the 74 oocytes (13.5%) demonstrated aneuploidy, four
(5.4%) oocytes were diploid and six (8.1%) oocytes were metaphase II with a
prematurely condensed sperm chromosome (PCC). In the tubal infertility
group, nine of the 73 (12.3%) oocytes showed aneuploidy, four (5.5%)
oocytes were diploid and five (6.8%) oocytes were found to have PCC. There
was no significant difference in the aneuploidy, diploidy and PCC rates
between the two groups. These results suggest that the reduced
fertilization observed in PCOS is not attributable to chromosomal
aberrations or immaturity of oocytes recruited from patients with PCOS.
ARTICLES
The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome
Department of Obstetrics and Gynecology, Asahikawa Medical College, Nishikagura, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Berker, C. Kaya, R. Aytac, and H. Satiroglu Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction Hum. Reprod., September 1, 2009; 24(9): 2293 - 2302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Hwang, K.-M. Seow, Y.-H. Lin, B.-C. Hsieh, L.-W. Huang, H.-J. Chen, S.-C. Huang, C.-Y. Chen, P.-H. Chen, and C.-R. Tzeng IVF versus ICSI in sibling oocytes from patients with polycystic ovarian syndrome: a randomized controlled trial Hum. Reprod., May 1, 2005; 20(5): 1261 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pellestor, T. Anahory, and S. Hamamah The chromosomal analysis of human oocytes. An overview of established procedures Hum. Reprod. Update, January 1, 2005; 11(1): 15 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pellestor, B. Andreo, F. Arnal, C. Humeau, and J. Demaille Mechanisms of non-disjunction in human female meiosis: the co-existence of two modes of malsegregation evidenced by the karyotyping of 1397 in-vitro unfertilized oocytes Hum. Reprod., August 1, 2002; 17(8): 2134 - 2145. [Abstract] [Full Text] [PDF]
|
|