Human Reproduction, Vol 12, 586-590, Copyright © 1997 by Oxford University Press
H Bokstrom, M Brannstrom, M Alexandersson and A Norstrom
Leukocyte subsets were detected by immunohistochemical methods in cervical
tissue in either the first trimester or at term pregnancy. In tissue
obtained during first trimester lower total numbers of leukocytes were
observed in comparison with late pregnancy (2.7 cells/0.04 mm2 versus 5.5
cells/0.04 mm2). The major subgroup of leukocytes present in early
pregnancy was T-lymphocytes. The majority of these cells were of the
suppressor/cytotoxic subtype. Neutrophils were present at about 1/5th of
the density of T-lymphocytes. Very few macrophages were observed at this
stage. At term pregnancy, neutrophils were present in significantly higher
numbers than during first trimester with no difference between tissue
obtained before or during active labour. Macrophages were present at about
10-fold higher density than during early pregnancy. In conclusion,
tissue-bound leukocytes are present in the human cervix at a higher density
in late pregnancy compared to first trimester. The increased densities of
neutrophils and macrophages at this stage indicate a role for these cells
during cervical ripening.
ARTICLES
Leukocyte subpopulations in the human uterine cervical stroma at early and term pregnancy
Department of Obstetrics and Gynecology, The Sahlgrenska University Hospital, Goteborg, Sweden.
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