Human Reproduction, Vol 12, 699-702, Copyright © 1997 by Oxford University Press
Y Yaron, A Amit, A Kogosowski, MR Peyser, MP David and JB Lessing
There has been growing concern about the number of multiple gestations
resulting from assisted reproductive technologies. For in-vitro
fertilization (IVF), there are guidelines concerning the number of embryos
to be transferred. In oocyte donation, however, there is a paucity of
studies addressing this issue and common practice is extrapolated from
standard IVF procedures. This may not be correct since endometrial
receptivity has been shown to be altered in oocyte donation. Thus the
purpose of this study was to assess the optimal number of embryos to be
transferred in oocyte donation. The study population included 254 patients
with ovarian failure who underwent a total of 601 embryo transfers in a
single shared oocyte donation programme. Pregnancy rates (PRs), multiple
pregnancies, triplet pregnancy rates, and implantation rates were evaluated
according to the number of embryos transferred. A significant linear
increase in PRs was noted with the increasing number of embryos transferred
up to five (11.1% for one embryo, 36.7% for five embryos). Multiple
pregnancies increased significantly from 15.8% for two embryos transferred,
to 44.4% for five embryos. The rate of triplet pregnancies also increased
from 2.7% for three embryos transferred, to 8.3% for five embryos.
Optimization of the number of embryos to be transferred is discussed.
ARTICLES
The optimal number of embryos to be transferred in shared oocyte donation: walking the thin line between low pregnancy rates and multiple pregnancies
Serlin Maternity Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel.
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