Human Reproduction, Vol 12, 746-751, Copyright © 1997 by Oxford University Press
RA Anderson, EM Wallace, NP Groome, AJ Bellis and FC Wu
Inhibin has been postulated to be secreted by Sertoli cells in response to
follicle stimulating hormone (FSH) and in turn to exert an inhibitory
effect on FSH production. We have investigated this relationship using an
assay specific for dimeric inhibin B. A total of 56 normal men received 200
mg testosterone enanthate (TE) i.m. weekly, for 65 +/- 1 weeks in a trial
of hormonal male contraception. Before treatment a significant negative
correlation between inhibin B and FSH concentration (r = 0.49, P <
0.001) was observed. During TE treatment, luteinizing hormone (LH) and FSH
were rapidly suppressed. This was followed by a parallel decline in inhibin
B and sperm concentration. During the early recovery phase, inhibin B
concentrations remained suppressed in men who showed a delay in resumption
of spermatogenesis, despite higher FSH concentrations. Inhibin B returned
to pretreatment concentrations after 24 weeks recovery, when the inverse
relationship with FSH was restored. Our results showed the expected inverse
physiological relationship between inhibin B and FSH in normal men, with a
decline during TE treatment and alpha subsequent resumption of the inverse
relationship during recovery. These data clearly support the hypothesis
that inhibin B plays a physiological role in the feedback control of FSH
secretion, and reflects FSH-stimulated Sertoli cell function.
ARTICLES
Physiological relationships between inhibin B, follicle stimulating hormone secretion and spermatogenesis in normal men and response to gonadotrophin suppression by exogenous testosterone
Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, University of Edinburgh, UK.
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